Total synthesis of terpenoids isolated from Caulerpale algae and their inhibition of tubulin assembly

被引：13

作者：

Commeiras, L

Bourdron, J

Douillard, S

Barbier, P

Vanthuyne, N

Peyrot, V ^{[1
]}

Parrain, JL

机构：

[1] Aix Marseille 2, FRE 2737, CNRS,Fac Pharm, Interact Entre Syst Prote Cellule Tumorales, Marseille, France

[2] Univ Paul Cezanne, UMR 6178, CNRS, Equipe Synth Voie Organomet, Marseille, France

[3] Univ Paul Cezanne, UMR 6180, Lab Stereochim Dynam & Chiralite, Marseille, France

来源：

SYNTHESIS-STUTTGART | 2006年 / 01期

关键词：

total synthesis; caulerpenyne; dihydrorhipocephalin; furocaulerpin; terpenoids; microtubule polymerisation;

D O I：

10.1055/s-2005-921760

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Total synthesis of four analogue terpenoids isolated from Caulerpa taxifolia was achieved in good yield with a total control of each double bond. Biological tests to compare the activities of in vitro tubulin polymerisation between the natural caulerpenyne and the synthetic caulerpenyne and its derivatives were also performed.

引用

页码：166 / 181

页数：16

共 53 条

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AMICO V, 1978, TETRAHEDRON LETT, P3593

[2]

ANDREU JM, 1990, ARCH BIOCHEM BIOPHYS, V279, P328

[3]

BAEKELMANS P, 1968, B SOC CHIM BELG, V77, P85

[4] Caulerpenyne from Caulerpa taxifolia has an antiproliferative activity on tumor cell line SK-N-SH and modifies the microtubule network [J].