Synthesis and antimicrobial agents of thiazolidinone derivatives from benzocyclohepetenone

被引：7

作者：

Jilla, Lavanya

Kolluri, Prashanth Kumar

Bujji, Sushmitha

J. P. Naikal, Subhashini ^{[1
,2
]}

机构：

[1] Osmania Univ, Dept Chem, Univ Coll Sci, Hyderabad 500007, Telangana, India

[2] Osmania Univ, Univ Coll Technol, Hyderabad 500007, Telangana, India

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2020年 / 57卷 / 11期

关键词：

BIOLOGICAL EVALUATION; 4-THIAZOLIDINONE; DESIGN; POTENT; ANTIBIOTICS;

D O I：

10.1002/jhet.4117

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of benzosuberone coupled piperazin-1-yl thiazolidin-4-one derivatives6a-jwere synthesized from 3-(2-[9-chloro-2,3-dimethyl-6,7-dihydro-5H-benzo[7]annulen-8-yl]-4-oxothiazolidin-3-yl)propanoic acid (4) and substituted piperazines/secondary amines5a-jusing 1-hydroxy benzotriazole, 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride and triethyl amine in good yields and their structures were characterized by(1)H NMR,C-13 NMR, IR, and Mass spectra. The newly synthesized compounds were evaluated for their antimicrobial activity against bacterial strains and a fungal strain. Compounds6fand6gwere indicated promising and broad spectrum antibacterial activity.

引用

收藏

页码：4078 / 4087

页数：10

相关论文

共 30 条

[1] Novel antibacterial agents for the treatment of serious Gram-positive infections [J].

Abbanat, D ;

Macielag, M ;

Bush, K .

EXPERT OPINION ON INVESTIGATIONAL DRUGS, 2003, 12 (03) :379-399

[2] Novel 2,4-dichlorophenoxy acetic acid substituted thiazolidin-4-ones as anti-inflammatory agents: Design, synthesis and biological screening [J].

Ali, Yakub ;

Alam, Mohammad Sarwar ;

Hamid, Hinna ;

Husain, Asif ;

Dhulap, Abhijeet ;

Bano, Sameena ;

Kharbanda, Chetna .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2017, 27 (04) :1017-1025

[3]

Amsterdam D, 1996, ANTIBIOTICSIN LAB ME, P52

[4] Synthesis and pharmacological screening of some novel antihypertensive agents possessing 5-Benzylidene-2-(phenylimino)-thiazolidin-4-one ring [J].

Bhalgat, Chetan M. ;

Darda, Pooja V. ;

Bothara, Kailash G. ;

Bhandari, Shashikant V. ;

Gandhi, Jotsna ;

Ramesh, B. .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2014, 76 :580-588

[5] Synthesis, biological evaluation and quantitative structure-active relationships of 1,3-thiazolidin-4-one derivatives. A promising chemical scaffold endowed with high antifungal potency and low cytotoxicity [J].

Carradori, Simone ;

Bizzarri, Bruna ;

D'Ascenzio, Melissa ;

De Monte, Celeste ;

Grande, Rossella ;

Rivanera, Daniela ;

Zicari, Alessanda ;

Mari, Emanuela ;

Sabatino, Manuela ;

Patsilinakos, Alexandros ;

Ragno, Rino ;

Secci, Daniela .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 140 :274-292

[6] Synthetic bicyclic iminosugar derivatives fused thiazolidin-4-one as new potential HIV-RT inhibitors [J].

Chen, Hua ;

Yang, Tianyu ;

Wei, Sinan ;

Zhang, Hongzhi ;

Li, Rui ;

Qin, Zhanbin ;

Li, Xiaoliu .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2012, 22 (23) :7041-7044

[7] The enantioselective construction of chiral spirooxindole-based 4-thiazolidinone via asymmetric catalytic formal [3+2] annulation using a bifunctional catalyst [J].

Cheng, Ping ;

Guo, Wengang ;

Chen, Ping ;

Liu, Yan ;

Du, Xin ;

Li, Can .

CHEMICAL COMMUNICATIONS, 2016, 52 (16) :3418-3421

[8] The future challenges facing the development of new antimicrobial drugs [J].

Coates, A ;

Hu, YM ;

Bax, R ;

Page, C .

NATURE REVIEWS DRUG DISCOVERY, 2002, 1 (11) :895-910

[9] FAVELANONE, A NOVEL TETRACYCLIC CYCLOPROPANE DERIVATIVE FROM THE BRAZILIAN PLANT, CNIDOSCOLUS-PHYLLACANTHUS [J].

ENDO, Y ;

OHTA, T ;

NOZOE, S .

TETRAHEDRON LETTERS, 1991, 32 (40) :5555-5558

[10] NOVEL 4-THIAZOLIDINONE DERIVATIVES AS AGONISTS OF BENZODIAZEPINE RECEPTORS: DESIGN, SYNTHESIS AND PHARMACOLOGICAL EVALUATION [J].

Faizi, Mehrdad ;

Jahani, Reza ;

Ebadi, Seyed Abbas ;

Tabatabai, Sayyed Abbas ;

Rezaee, Elham ;

Lotfaliei, Mehrnaz ;

Amini, Mohsen ;

Almasirad, Ali .

EXCLI JOURNAL, 2017, 16 :52-62