Pediatric human immunodeficiency virus infection and circulating IgD+ memory B cells

被引：23

作者：

Jacobsen, Marianne C. ^{[1
]}

Thiebaut, Rodolphe ^{[1
,3
]}

Fisher, Christopher ^{[1
]}

Sefe, Delali ^{[1
]}

Clapson, Margaret ^{[2
]}

Klein, Nigel ^{[1
]}

Baxendale, Helen E. ^{[1
]}

机构：

[1] UCL, Inst Child Hlth, Hugh & Catherine Stevenson Ctr Childhood Infect D, Infect Dis & Microbiol Unit, London WC1N 1EH, England

[2] Great Ormond St Hosp Sick Children, Dept Infect Dis, London WC1N 3JH, England

[3] INSERM, U897, Bordeaux, France

来源：

JOURNAL OF INFECTIOUS DISEASES | 2008年 / 198卷 / 04期

关键词：

D O I：

10.1086/590215

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Levels of circulating naive and memory B cells were measured in human immunodeficiency virus (HIV)-infected children and control subjects to determine whether the irreversible depletion of memory B cells described in HIV-infected adults occurs in children with HIV infection. Depletion of circulating IgD(+) memory B cells was seen in HIV-infected children despite control of the HIV load with highly active antiretroviral therapy (HAART) (P = .04). IgD(+) memory B cell percentages did not correlate with CD4(+) cell percentages (P = .27) or disease duration (P = .26). Naive/transitional and IgD(+) memory B cell numbers were not affected. Pediatric HIV infection is associated with selective depletion of circulating IgD(+) memory B cells despite control of the HIV load with HAART.

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页码：481 / 485

页数：5

相关论文

共 16 条

[1] Cutting edge: Selection of B lymphocyte subsets is regulated by natural IgM [J].

Baker, N ;

Ehrenstein, MR .

JOURNAL OF IMMUNOLOGY, 2002, 169 (12) :6686-6690

[2] The evidence for using conjugate vaccines to protect HIV-infected children against pneumococcal disease [J].

Bliss, Sandra J. ;

O'Brien, Katherine L. ;

Janoff, Edward N. ;

Cotton, Mark F. ;

Musoke, Philippa ;

Coovadia, Hoosen ;

Levine, Orin S. .

LANCET INFECTIOUS DISEASES, 2008, 8 (01) :67-80

[3] A pneumococcal capsular polysaccharide vaccine induces a repertoire shift with increased VH3 expression in peripheral B cells from human immunodeficiency virus (HIV)-uninfected but not HIV-infected persons [J].

Chang, Q ;

Abadi, J ;

Alpert, P ;

Pirofski, L .

JOURNAL OF INFECTIOUS DISEASES, 2000, 181 (04) :1313-1321

[4] Circulating memory B-cell subpopulations are affected differently by HIV infection and antiretroviral therapy [J].

D'Orsogna, Lloyd J. ;

Krueger, Rom G. ;

McKinnon, Elizabeth J. ;

French, Martyn A. .

AIDS, 2007, 21 (13) :1747-1752

[5] B lymphocyte dysfunctions in HIV infection [J].

De Milito, A .

CURRENT HIV RESEARCH, 2004, 2 (01) :11-21

[6] Susceptibility to opportunistic infections in HIV-infected patients with increased CD4 T-cell counts on antiretroviral therapy may be predicted by markers of dysfunctional effector memory CD4 T cells and B cells [J].

French, M. A. ;

Keane, N. M. ;

McKinnon, E. J. ;

Phung, S. ;

Price, P. .

HIV MEDICINE, 2007, 8 (03) :148-155

[7]

*GRAPHPAD, GRAPHPAD COMP PROGR

[8] Loss of discrete memory B cell subsets is associated with impaired immunization responses in HIV-1 infection and may be a risk factor for invasive pneumococcal disease [J].

Hart, Melanie ;

Steel, Alan ;

Clark, Sally A. ;

Moyle, Graeme ;

Nelson, Mark ;

Henderson, Don C. ;

Wilson, Robert ;

Gotch, Frances ;

Gazzard, Brian ;

Kelleher, Peter .

JOURNAL OF IMMUNOLOGY, 2007, 178 (12) :8212-8220

[9] The impact of HIV on Streptococcus pneumoniae bacteraemia in a South African population [J].

Jones, N ;

Huebner, R ;

Khoosal, M ;

Crewe-Brown, H ;

Klugman, K .

AIDS, 1998, 12 (16) :2177-2184

[10] HIV and pneumococcal disease [J].

Klugman, Keith P. ;

Madhi, Shabir A. ;

Feldman, Charles .

CURRENT OPINION IN INFECTIOUS DISEASES, 2007, 20 (01) :11-15