SW-163A and B, novel immunosuppressants produced by Streptomyces sp.

被引：20

作者：

Takahashi, K ^{[1
]}

Tsuda, E ^{[1
]}

Kurosawa, K ^{[1
]}

机构：

[1] Snow Brand Milk Prod Co Ltd, Life Sci Res Inst, Ishibashi, Tochigi 3290512, Japan

来源：

JOURNAL OF ANTIBIOTICS | 2001年 / 54卷 / 11期

关键词：

D O I：

10.7164/antibiotics.54.867

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

SW-163A and B, novel immunosuppressants, were isolated from the culture broth of Streptomyces sp. SNA15896. The molecular formulas of SW-163A and B were determined as C34H42N2O12 and C33H40N2O12 based on the HRFAB-MS analysis, respectively. Both compounds were elucidated to be a large ring ester structure through spectroscopic analyses including various NMR measurements. SW-163A and B showed immunosuppressive and antimicrobial activities in vitro.

引用

页码：867 / 873

页数：7

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