Solid phase synthesis of a metronidazole oligonucleotide conjugate

被引：1

作者：

Walsh, Andrew J. ^{[1
]}

Davis, Michael L. ^{[1
]}

Fraser, William ^{[1
]}

机构：

[1] Aston Univ, Sch Life & Hlth Sci, Birmingham B4 7ET, W Midlands, England

来源：

MOLECULES | 2006年 / 11卷 / 06期

关键词：

CPG; conjugate; metronidazole; oligonucleotide; phosphoramidite; solid phase;

D O I：

10.3390/11060486

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Direct, solid phase synthesis of an oligonucleotide conjugate of the antibiotic drug metronidazole was accomplished by the phosphoramidite method. Removal of protecting groups and cleavage from the controlled pore glass (CPG) solid support was successful using mild conditions (20% Et3N in pyridine, then conc. NH3 (aq) at rt for 30 min) whereas standard conditions (conc. NH3 (aq) at 55 degrees C for 16 h) cleaved the drug.

引用

页码：486 / 495

页数：10

共 32 条

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