Molecular Recognition Models: A Challenge to Overcome

被引：15

作者：

Caceres, Rafael Andrade ^{[1
,2
]}

Pauli, Ivani ^{[1
]}

Saraiva Macedo Timmers, Luis Fernando ^{[1
]}

de Azevedo, Walter Filgueira, Jr. ^{[1
,2
]}

机构：

[1] Pontificia Univ Catolica Rio Grande do Sul, Fac Biociencias, Lab Bioquim Estrutural, Porto Alegre, RS, Brazil

[2] Pontificia Univ Catolica Rio Grande do Sul, Programa Posgrad Med & Ciencias Saude, Porto Alegre, RS, Brazil

来源：

CURRENT DRUG TARGETS | 2008年 / 9卷 / 12期

关键词：

Binding affinity; molecular recognition; protein-ligand; drug-design;

D O I：

10.2174/138945008786949414

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Molecular recognition process describes the interaction involving two molecules. In the case of biomolecules, these pairs of molecules could be protein-protein, protein-ligand or protein-nucleic acid. The first model to capture the essential features, behind the molecular recognition problem, was the lock-and-key paradigm. The overall analysis protein-protein, protein-nucleic acid and protein-ligand interaction based on the three-dimensional structures and physicochemical parameters, such as binding affinity, opened the possibility to provide further insights in this basic phenomenon. The main ideas behind the molecular recognition are discussed in the present review.

引用

页码：1077 / 1083

页数：7

共 96 条

[1] Opioid diketopiperazines: Synthesis and activity of a prototypic class of opioid antagonists [J].