[1] Univ Western Ontario, Dept Med, Div Clin Pharmacol, London, ON, Canada
[2] Univ Western Ontario, Dept Physiol & Pharmacol, London, ON, Canada
[3] Univ Western Ontario, Dept Oncol, London, ON, Canada
[4] Univ Western Ontario, Dept Surg, London, ON N6A 3K7, Canada
[5] Univ Western Ontario, Dept Epidemiol & Biostat, London, ON, Canada
[6] LHSC Univ Hosp, Dept Med, London, ON N6A 5A5, Canada