Zinc and Skin Disorders

被引：148

作者：

Ogawa, Youichi ^{[1
]}

Kinoshita, Manao ^{[1
]}

Shimada, Shinji ^{[1
]}

Kawamura, Tatsuyoshi ^{[1
]}

机构：

[1] Univ Yamanashi, Dept Dermatol, Fac Med, Yamanashi 4093898, Japan

来源：

NUTRIENTS | 2018年 / 10卷 / 02期

基金：

日本学术振兴会; 英国科研创新办公室;

关键词：

zinc; skin; acrodermatitis enteropathica; Langerhans cells; ATP; nutrition; NECROLYTIC MIGRATORY ERYTHEMA; EPIDERMAL LANGERHANS CELLS; FATTY-ACID COMPOSITION; EHLERS-DANLOS-SYNDROME; TRACE-METAL LEVELS; LOW SERUM ZINC; BIOTIN DEFICIENCY; AMINO-ACID; ACRODERMATITIS-ENTEROPATHICA; ALOPECIA-AREATA;

D O I：

10.3390/nu10020199

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

The skin is the third most zinc (Zn)-abundant tissue in the body. The skin consists of the epidermis, dermis, and subcutaneous tissue, and each fraction is composed of various types of cells. Firstly, we review the physiological functions of Zn and Zn transporters in these cells. Several human disorders accompanied with skin manifestations are caused by mutations or dysregulation in Zn transporters; acrodermatitis enteropathica (Zrt-, Irt-like protein (ZIP)4 in the intestinal epithelium and possibly epidermal basal keratinocytes), the spondylocheiro dysplastic form of Ehlers-Danlos syndrome (ZIP13 in the dermal fibroblasts), transient neonatal Zn deficiency (Zn transporter (ZnT)2 in the secretory vesicles of mammary glands), and epidermodysplasia verruciformis (ZnT1 in the epidermal keratinocytes). Additionally, acquired Zn deficiency is deeply involved in the development of some diseases related to nutritional deficiencies (acquired acrodermatitis enteropathica, necrolytic migratory erythema, pellagra, and biotin deficiency), alopecia, and delayed wound healing. Therefore, it is important to associate the existence of mutations or dysregulation in Zn transporters and Zn deficiency with skin manifestations.

引用

页数：19

共 169 条

[21] Intracellular zinc depletion induces caspase activation and p21Waf1/Cip1 cleavage in human epithelial cell lines [J].