Role and potential mechanisms of anabolic resistance in sarcopenia

被引:123
作者
Haran, Prashanth H. [1 ]
Rivas, Donato A. [1 ]
Fielding, Roger A. [1 ]
机构
[1] Tufts Univ, Jean Mayer USDA Human Nutr Res Ctr Aging, Nutr Exercise Physiol & Sarcopenia Lab, Boston, MA 02111 USA
关键词
Sarcopenia; Anabolic resistance; Skeletal muscle; MUSCLE PROTEIN-SYNTHESIS; HYDROXY-BETA-METHYLBUTYRATE; SKELETAL-MUSCLE; INSULIN-RESISTANCE; AMINO-ACIDS; WHOLE-BODY; ELDERLY POPULATION; AGE; EXERCISE; MTOR;
D O I
10.1007/s13539-012-0068-4
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
There is pressing need to understand the aging process to better cope with its associated physical and societal costs. The age-related muscle wasting known as sarcopenia is a major contributor to the problems faced by the elderly. By hindering mobility and reducing strength, it greatly diminishes independence and quality of life. In studying the factors that contribute to the development of sarcopenia, the focus is shifting to the study of disordered muscle anabolism. The abnormal response of muscle to previously well-established anabolic stimuli is known as anabolic resistance, and may be a key factor in the development and progression of sarcopenia. Factors such as age, obesity, inflammation, and lipotoxicity contribute to anabolic resistance, and have been studied either directly or indirectly in cell systems and whole animals. Understanding the physiologic and mechanistic basis of anabolic resistance could be the key to formulating new and targeted interventions that would ease the burden currently borne by the world's aged population.
引用
收藏
页码:157 / 162
页数:6
相关论文
共 67 条
[1]   The relationships among IGF-1, DNA content, and protein accumulation during skeletal muscle hypertrophy [J].
Adams, GR ;
Haddad, F .
JOURNAL OF APPLIED PHYSIOLOGY, 1996, 81 (06) :2509-2516
[2]   Epidemiology of sarcopenia among the elderly in New Mexico [J].
Baumgartner, RN ;
Koehler, KM ;
Gallagher, D ;
Romero, L ;
Heymsfield, SB ;
Ross, RR ;
Garry, PJ ;
Lindeman, RD .
AMERICAN JOURNAL OF EPIDEMIOLOGY, 1998, 147 (08) :755-763
[3]  
Baumgartner RN, 2000, ANN NY ACAD SCI, V904, P437
[4]   EUGLYCEMIC HYPERINSULINEMIA AUGMENTS AMINO-ACID-UPTAKE BY HUMAN LEG TISSUES DURING HYPERAMINOACIDEMIA [J].
BENNET, WM ;
CONNACHER, AA ;
SCRIMGEOUR, CM ;
JUNG, RT ;
RENNIE, MJ .
AMERICAN JOURNAL OF PHYSIOLOGY, 1990, 259 (02) :E185-E194
[5]   PHYSIOLOGICAL HYPERINSULINEMIA STIMULATES PROTEIN-SYNTHESIS AND ENHANCES TRANSPORT OF SELECTED AMINO-ACIDS IN HUMAN SKELETAL-MUSCLE [J].
BIOLO, G ;
FLEMING, RYD ;
WOLFE, RR .
JOURNAL OF CLINICAL INVESTIGATION, 1995, 95 (02) :811-819
[6]   Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo [J].
Bodine, SC ;
Stitt, TN ;
Gonzalez, M ;
Kline, WO ;
Stover, GL ;
Bauerlein, R ;
Zlotchenko, E ;
Scrimgeour, A ;
Lawrence, JC ;
Glass, DJ ;
Yancopoulos, GD .
NATURE CELL BIOLOGY, 2001, 3 (11) :1014-1019
[7]   siRNA-based gene silencing reveals specialized roles of IRS-1/Akt2 and IRS-2/Akt1 in glucose and lipid metabolism in human skeletal muscle [J].
Bouzakri, Karim ;
Zachrisson, Anna ;
Al-Khalili, Lubna ;
Zhang, Bei B. ;
Koistinen, Heikki A. ;
Krook, Anna ;
Zierath, Juleen R. .
CELL METABOLISM, 2006, 4 (01) :89-96
[8]   A role for protein phosphatase 2A-like activity, but not atypical protein kinase Cζ, in the inhibition of protein kinase B/Akt and glycogen synthesis by palmitate [J].
Cazzolli, R ;
Carpenter, L ;
Biden, TJ ;
Schmitz-Peiffer, C .
DIABETES, 2001, 50 (10) :2210-2218
[9]   Sarcopenia, obesity, and inflammation - results from the Trial of Angiotensin Converting Enzyme Inhibition and Novel Cardiovascular Risk Factors study [J].
Cesari, M ;
Kritchevsky, SB ;
Baumgartner, RN ;
Atkinson, HH ;
Penninx, BWHJ ;
Lenchik, L ;
Palla, SL ;
Ambrosius, WT ;
Tracy, RP ;
Pahor, M .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 2005, 82 (02) :428-434
[10]   Vascular biomarkers of cognitive performance in a community-based elderly population: the Dublin Healthy Ageing study [J].
Chin, Al-Vyrn ;
Robinson, David J. ;
O'Connell, Henry ;
Hamilton, Fiona ;
Bruce, Irene ;
Coen, Robert ;
Walsh, Bernard ;
Coakley, Davis ;
Molloy, Anne ;
Scott, John ;
Lawlor, Brian A. ;
Cunningham, Conal J. .
AGE AND AGEING, 2008, 37 (05) :559-564