Umbilical cord blood transplantation: the first 25 years and beyond

被引：506

作者：

Ballen, Karen K. ^{[1
]}

Gluckman, Eliane ^{[2
]}

Broxmeyer, Hal E. ^{[3
]}

机构：

[1] Massachusetts Gen Hosp, Ctr Canc, Boston, MA 02114 USA

[2] Univ Paris Diderot, Eurocord Hosp St Louis, APHP, Paris, France

[3] Indiana Univ Sch Med, Indianapolis, IN 46202 USA

来源：

BLOOD | 2013年 / 122卷 / 04期

关键词：

MULTIPOTENTIAL PROGENITOR CELLS; BONE-MARROW-TRANSPLANTATION; ANTI-HLA ANTIBODIES; HEMATOPOIETIC STEM; UNRELATED DONOR; ACUTE-LEUKEMIA; FANCONI-ANEMIA; CONDITIONING REGIMEN; ENHANCE ENGRAFTMENT; ADULT RECIPIENTS;

D O I：

10.1182/blood-2013-02-453175

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Umbilical cord blood is an alternative hematopoietic stem cell source for patients with hematologic diseases who can be cured by allogeneic hematopoietic cell transplantation. Initially, umbilical cord blood transplantation was limited to children, given the low cell dose infused. Both related and unrelated cord blood transplants have been performed with high rates of success for a variety of hematologic disorders and metabolic storage diseases in the pediatric setting. The results for adult umbilical cord blood transplantation have improved, with greater emphasis on cord blood units of sufficient cell dose and human leukocyte antigen match and with the use of double umbilical cord blood units and improved supportive care techniques. Cord blood expansion trials have recently shown improvement in time to engraftment. Umbilical cord blood is being compared with other graft sources in both retrospective and prospective trials. The growth of the field over the last 25 years and the plans for future exploration are discussed.

引用

页码：491 / 498

页数：8

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