The role of adipose tissue and excess of fatty acids in the induction of insulin resistance in skeletal muscle

被引：0
作者：
Chacinska, Marta [1 ]
Zabielski, Piotr [3 ]
Grycel, Slawomir [2 ]
Blachnio-Zabielska, Agnieszka [1 ]
机构：
[1] Uniwersytet Med Bialymstoku, Zaklad Higieny Epidemiol & Zaburzen Metab, Ul Mickiewicza 2c, PL-15204 Bialystok, Poland
[2] NZOZ Specjalistyczny Osrodek Med SOMED Poradnia D, Lomza, Poland
[3] Uniwersytet Med Bialymstoku, Zaklad Biol Ogolnej, Bialystok, Poland
来源：
POSTEPY HIGIENY I MEDYCYNY DOSWIADCZALNEJ | 2016年 / 70卷
关键词：
insulin resistance; skeletal muscle; ceramide; diacylglycerol; long-chain acyl-CoA; PHOSPHATIDYLINOSITOL 3-KINASE ACTIVITY; PROTEIN-KINASE-C; LIPID-METABOLISM; SPHINGOLIPID METABOLISM; RECEPTOR SUBSTRATE-1; GLUCOSE-TRANSPORT; CERAMIDE CONTENT; BINDING-PROTEIN; ACYL-COA; OBESITY;
D O I：
暂无
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Skeletal muscle is the main tissue responsible for insulin-stimulated glucose uptake. Consumption of a high-fat diet rich in saturated fats (HFD) and obesity are associated with accumulation of intramuscular lipids that leads to several disorders, e. g. insulin resistance (IRes) and type 2 diabetes (T2D). The mechanism underlying the induction of IRes is still unknown. It was speculated that accumulation of intramuscular triacylglycerols (TAG) is linked to induction of IRes. Now, research focuses on bioactive lipids: long-chain acyl-CoA (LCACoA), diacylglycerols (DAG) and ceramides (Cer). It has been demonstrated that accumulation of each of the above- mentioned lipid classes negatively affects the insulin signaling pathway. It is not clear which of those lipids play the most important role in HFD-induced skeletal muscle IRes. The aim of the present work is to present the current knowledge of the role of adipose tissue and excess of fatty acids in the induction of insulin resistance.
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页码：1142 / 1149
页数：8
相关论文
共 56 条
[1]  
Abumrad N, 1998, J LIPID RES, V39, P2309
[2]   Ceramide content is increased in skeletal muscle from obese insulin-resistant humans [J].
Adams, JM ;
Pratipanawatr, T ;
Berria, R ;
Wang, E ;
DeFronzo, RA ;
Sullards, MC ;
Mandarino, LJ .
DIABETES, 2004, 53 (01) :25-31
[3]   Adipose tissue and its relation to inflammation:: The role of adipokines [J].
Axelsson, J ;
Heimbürger, O ;
Lindholm, B ;
Stenvinkel, P .
JOURNAL OF RENAL NUTRITION, 2005, 15 (01) :131-136
[4]   Dose-response effect of elevated plasma free fatty acid on insulin signaling [J].
Belfort, R ;
Mandarino, L ;
Kashyap, S ;
Wirfel, K ;
Pratipanawatr, T ;
Berria, R ;
DeFronzo, RA ;
Cusi, K .
DIABETES, 2005, 54 (06) :1640-1648
[5]   METABOLIC IMPLICATIONS OF BODY-FAT DISTRIBUTION [J].
BJORNTORP, P .
DIABETES CARE, 1991, 14 (12) :1132-1143
[6]   Ceramide metabolism is affected by obesity and diabetes in human adipose tissue [J].
Blachnio-Zabielska, A. U. ;
Pulka, M. ;
Baranowski, M. ;
Nikolajuk, A. ;
Zabielski, P. ;
Gorska, M. ;
Gorski, J. .
JOURNAL OF CELLULAR PHYSIOLOGY, 2012, 227 (02) :550-557
[7]   Effect of High Fat Diet Enriched With Unsaturated and Diet Rich in Saturated Fatty Acids on Sphingolipid Metabolism in Rat Skeletal Muscle [J].
Blachnio-Zabielska, Agnieszka ;
Baranowski, Marcin ;
Zabielski, Piotr ;
Gorski, Jan .
JOURNAL OF CELLULAR PHYSIOLOGY, 2010, 225 (03) :786-791
[8]   Sphingolipid Content of Human Adipose Tissue: Relationship to Adiponectin and Insulin Resistance [J].
Blachnio-Zabielska, Agnieszka U. ;
Koutsari, Christina ;
Tchkonia, Tamara ;
Jensen, Michael D. .
OBESITY, 2012, 20 (12) :2341-2347
[9]   Increased Bioactive Lipids Content in Human Subcutaneous and Epicardial Fat Tissue Correlates with Insulin Resistance [J].
Blachnio-Zabielska, Agnieszka U. ;
Baranowski, Marcin ;
Hirnle, Tomasz ;
Zabielski, Piotr ;
Lewczuk, Anna ;
Dmitruk, Iwona ;
Gorski, Jan .
LIPIDS, 2012, 47 (12) :1131-1141
[10]   Fatty acid transporters (FABPpm, FAT, FATP) in human muscle [J].
Bonen, A ;
Miskovic, D ;
Kiens, B .
CANADIAN JOURNAL OF APPLIED PHYSIOLOGY-REVUE CANADIENNE DE PHYSIOLOGIE APPLIQUEE, 1999, 24 (06) :515-523
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