Role of central arginine vasopressin receptors in the analgesic effect of CDP-choline on acute and neuropathic pain

被引：9

作者：

Bagdas, Deniz ^{[1
]}

Yucel-Ozboluk, Hasret ^{[2
]}

Orhan, Fulya ^{[2
]}

Kanat, Ozkan ^{[2
]}

Isbil-Buyukcoskun, Naciye ^{[3
]}

Gurun, Mine S. ^{[2
]}

机构：

[1] Uludag Univ, Fac Med, Expt Anim Breeding & Res Ctr, Bursa, Turkey

[2] Uludag Univ, Fac Med, Dept Pharmacol, Bursa, Turkey

[3] Uludag Univ, Fac Med, Dept Physiol, Bursa, Turkey

来源：

NEUROREPORT | 2013年 / 24卷 / 17期

关键词：

acute pain; analgesia; arginine vasopressin; CDP-choline; neuropathic pain; PERIAQUEDUCTAL GRAY; ANTINOCICEPTION; RAT; INVOLVEMENT; NOCICEPTION; NUCLEI; MODELS;

D O I：

10.1097/WNR.0000000000000009

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Recent studies have demonstrated that arginine vasopressin (AVP) plays a crucial role in pain modulation. In addition, our previous studies have proven that centrally administered cytidine-5-diphosphate-choline (CDP-choline; citicoline) elicits an analgesic effect in different pain models in rats. Given that CDP-choline enhances central and peripheral vasopressin levels, the present study was designed to investigate the role of central AVP receptors in the analgesic effect of CDP-choline in acute and chronic constriction injury-induced neuropathic pain models. For this purpose, rats were pretreated intracerebroventricularly with the AVP V-1 or AVP V-2 receptor antagonist 15 min before intracerebroventricular injection of CDP-choline or saline, and pain threshold was determined using the Randall-Selitto test. AVP V-1 and AVP V-2 receptor antagonist blocked the CDP-choline-induced analgesic effect either in acute or neuropathic models of pain in rats. These results suggest, for the first time, that central AVP receptors are involved in the CDP-choline-elicited analgesic effect. (C) 2013 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.

引用

页码：941 / 946

页数：6

共 24 条

[1] Cytidine 5′-diphosphocholine (CDP-choline) in stroke and other CNS disorders [J].

Adibhatla, R ;

Hatcher, JF .

NEUROCHEMICAL RESEARCH, 2005, 30 (01) :15-23

[2] The antihyperalgesic effect of cytidine-5′-diphosphate-choline in neuropathic and inflammatory pain models [J].

Bagdas, Deniz ;

Sonat, Fusun Ak ;

Hamurtekin, Emre ;

Sonal, Songul ;

Gurun, Mine Sibel .

BEHAVIOURAL PHARMACOLOGY, 2011, 22 (5-6) :589-598

[3] Centrally injected CDP-choline increases plasma vasopressin levels by central cholinergic activation [J].

Cavun, S ;

Savci, V ;

Ulus, IH .

FUNDAMENTAL & CLINICAL PHARMACOLOGY, 2004, 18 (01) :71-77

[4] Intravenous CDP-choline activates neurons in supraoptic and paraventricular nuclei and induces hormone secretion [J].

Eyigor, Ozhan ;

Coskun, Cenk ;

Cavun, Sinan ;

Savci, Vahide .

BRAIN RESEARCH BULLETIN, 2012, 87 (2-3) :286-294

[5] The Effect of Peripherally Administered CDP-Choline in an Acute Inflammatory Pain Model: The Role of α7 Nicotinic Acetylcholine Receptor [J].

Gurun, Mine Sibel ;

Parker, Renee ;

Eisenach, James C. ;

Vincler, Michelle .

ANESTHESIA AND ANALGESIA, 2009, 108 (05) :1680-1687

[6] Possible involvement of supraspinal opioid and GABA receptors in CDP-choline-induced antinociception in acute pain models in rats [J].

Hamurtekin, Emre ;

Bagdas, Deniz ;

Gurun, M. Sibel .

NEUROSCIENCE LETTERS, 2007, 420 (02) :116-121

[7] The antinociceptive effects of centrally administered CDP-choline on acute [J].

Hamurtekin, Emre ;

Gurun, M. Sibel .

BRAIN RESEARCH, 2006, 1117 :92-100

[8] New Topics in Vasopressin Receptors and Approach to Novel Drugs: Involvement of Vasopressin V1a and V1b Receptors in Nociceptive Responses and Morphine-Induced Effects [J].

Honda, Kenji ;

Takano, Yukio .

JOURNAL OF PHARMACOLOGICAL SCIENCES, 2009, 109 (01) :38-43

[9] VASOPRESSIN ANALGESIA - SPECIFICITY OF ACTION AND NON-OPIOID EFFECTS [J].

KORDOWER, JH ;

BODNAR, RJ .

PEPTIDES, 1984, 5 (04) :747-756

[10]

Li XY, 2011, WORLD J NEUROSCI, V1, P49

← 1 2 3 →