MicroRNA-profiling in breast- and salivary gland-derived adenoid cystic carcinomas

被引：3

作者：

Kiss, Orsolya ^{[1
]}

Tokes, Anna-Maria ^{[3
]}

Spisak, Sandor ^{[2
]}

Szilagyi, Anna ^{[4
]}

Lippai, Norbert ^{[5
]}

Szasz, A. Marcell ^{[1
]}

Kulka, Janina ^{[1
]}

机构：

[1] Semmelweis Egyet, Altalanos Orvostudomanyi Kar, Patol Intezet 2, Budapest, Hungary

[2] Semmelweis Egyet, Altalanos Orvostudomanyi Kar, Belgyogyaszati Klin 2, Budapest, Hungary

[3] Magyar Tudomanyos Akad Semmelweis Egyet, Daganatprogresszio Kutatocsoport, Budapest, Hungary

[4] Szent Gyorgy Korhaz, Szekesfeherver, Hungary

[5] Jasz Nagykun Szolnok Megyei Hetenyi Geza Korhaz, Szolnok, Hungary

来源：

ORVOSI HETILAP | 2013年 / 154卷 / 25期

关键词：

adenoid cystic carcinoma; micro-RNA; breast; salivary gland; EXPRESSION PATTERNS; MYB; BIOMARKERS; INVASION; FUSION; HEAD;

D O I：

10.1556/OH.2013.29643

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Introduction: Adenoid cystic carcinoma is a salivary gland-derived malignant tumor, but rarely it can originate from the breast, too. The salivary gland-derived form shows a very aggressive clinical outcome, while adenoid cystic carcinoma of the breast has mostly a very good prognosis. Aim: The aim of the authors was to compare the miRNA-expression profile of breast-and salivary gland-derived cases. Method: The miRNA-profiles of two salivary gland derived and two breast-derived adenoid cystic carcinoma tissues as well as one normal breast and one salivary gland tissues were analysed using the Affymetrix (R) Gene Chip. Results: The expression of some miRNAs differed in the tumor tissues compared to their controls: the let-7b was overexpressed in salivary gland-derived adenoid cystic carcinoma, while decreased in breast-derived adenoid cystic carcinoma. In addition, the miR-24 was decreased in salivary gland-derived but overexpressed in breast-derived adenoid cystic carcinomas. The miR-181a-2* was only detected in salivary gland-derived adenoid cystic carcinomas. Conclusions: Through post-transcriptional regulation of the genes, the diverse expression of some miRNAs may partially explain the diverse clinical outcome of salivary gland-derived and breast-derived adenoid cystic carcinomas.

引用

页码：963 / 968

页数：6

共 35 条

[11] Embryonic stem cell-specific MicroRNAs [J].

Houbaviy, HB ;

Murray, MF ;

Sharp, PA .

DEVELOPMENTAL CELL, 2003, 5 (02) :351-358

[12] MicroRNA let-7a suppresses breast cancer cell migration and invasion through downregulation of C-C chemokine receptor type 7 [J].

Kim, Seok-Jun ;

Shin, Ji-Young ;

Lee, Kang-Duck ;

Bae, Young-Ki ;

Sung, Ki Woong ;

Nam, Seok Jin ;

Chun, Kyung-Hee .

BREAST CANCER RESEARCH, 2012, 14 (01)

[13] Obesity-induced overexpression of miR-802 impairs glucose metabolism through silencing of Hnf1b [J].

Kornfeld, Jan-Wilhelm ;

Baitzel, Catherina ;

Koenner, A. Christine ;

Nicholls, Hayley T. ;

Vogt, Merly C. ;

Herrmanns, Karolin ;

Scheja, Ludger ;

Haumaitre, Cecile ;

Wolf, Anna M. ;

Knippschild, Uwe ;

Seibler, Jost ;

Cereghini, Silvia ;

Heeren, Joerg ;

Stoffel, Markus ;

Bruening, Jens C. .

NATURE, 2013, 494 (7435) :111-115

[14] Oncogenic microRNAs (OncomiRs) as a new class of cancer biomarkers [J].

Krutovskikh, Vladimir A. ;

Herceg, Zdenko .

BIOESSAYS, 2010, 32 (10) :894-904

[15] MicroRNA Expression and Clinical Outcome of Small Cell Lung Cancer [J].

Lee, Jih-Hsiang ;

Voortman, Johannes ;

Dingemans, Anne-Marie C. ;

Voeller, Donna M. ;

Pham, Trung ;

Wang, Yisong ;

Giaccone, Giuseppe .

PLOS ONE, 2011, 6 (06)

[16]

Lendvai Gabor, 2012, Orvosi Hetilap, V153, P978, DOI 10.1556/OH.2012.29387

[17] MicroRNAs and Atherosclerosis [J].

Madrigal-Matute, Julio ;

Rotllan, Noemi ;

Aranda, Juan F. ;

Fernandez-Hernando, Carlos .

CURRENT ATHEROSCLEROSIS REPORTS, 2013, 15 (05)

[18] Adenoid cystic carcinomas of the breast and salivary glands (or 'The strange case of Dr Jekyll and Mr Hyde' of exocrine gland carcinomas) [J].

Marchio, Caterina ;

Weigelt, Britta ;

Reis-Filho, Jorge S. .

JOURNAL OF CLINICAL PATHOLOGY, 2010, 63 (03) :220-228

[19] MYB Is Essential for Mammary Tumorigenesis [J].

Miao, Rebecca Yu ;

Drabsch, Yvette ;

Cross, Ryan Stanley ;

Cheasley, Dane ;

Carpinteri, Sandra ;

Pereira, Lloyd ;

Malaterre, Jordane ;

Gonda, Thomas J. ;

Anderson, Robin L. ;

Ramsay, Robert G. .

CANCER RESEARCH, 2011, 71 (22) :7029-7037

[20] Comprehensive Analysis of the MYB-NFIB Gene Fusion in Salivary Adenoid Cystic Carcinoma: Incidence, Variability, and Clinicopathologic Significance [J].

Mitani, Yoshitsugu ;

Li, Jie ;

Rao, Pulivarthi H. ;

Zhao, Yi-Jue ;

Bell, Diana ;

Lippman, Scott M. ;

Weber, Randal S. ;

Caulin, Carlos ;

El-Naggar, Adel K. .

CLINICAL CANCER RESEARCH, 2010, 16 (19) :4722-4731

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