MicroRNA-profiling in breast- and salivary gland-derived adenoid cystic carcinomas

被引：3

作者：

Kiss, Orsolya ^{[1
]}

Tokes, Anna-Maria ^{[3
]}

Spisak, Sandor ^{[2
]}

Szilagyi, Anna ^{[4
]}

Lippai, Norbert ^{[5
]}

Szasz, A. Marcell ^{[1
]}

Kulka, Janina ^{[1
]}

机构：

[1] Semmelweis Egyet, Altalanos Orvostudomanyi Kar, Patol Intezet 2, Budapest, Hungary

[2] Semmelweis Egyet, Altalanos Orvostudomanyi Kar, Belgyogyaszati Klin 2, Budapest, Hungary

[3] Magyar Tudomanyos Akad Semmelweis Egyet, Daganatprogresszio Kutatocsoport, Budapest, Hungary

[4] Szent Gyorgy Korhaz, Szekesfeherver, Hungary

[5] Jasz Nagykun Szolnok Megyei Hetenyi Geza Korhaz, Szolnok, Hungary

来源：

ORVOSI HETILAP | 2013年 / 154卷 / 25期

关键词：

adenoid cystic carcinoma; micro-RNA; breast; salivary gland; EXPRESSION PATTERNS; MYB; BIOMARKERS; INVASION; FUSION; HEAD;

D O I：

10.1556/OH.2013.29643

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Introduction: Adenoid cystic carcinoma is a salivary gland-derived malignant tumor, but rarely it can originate from the breast, too. The salivary gland-derived form shows a very aggressive clinical outcome, while adenoid cystic carcinoma of the breast has mostly a very good prognosis. Aim: The aim of the authors was to compare the miRNA-expression profile of breast-and salivary gland-derived cases. Method: The miRNA-profiles of two salivary gland derived and two breast-derived adenoid cystic carcinoma tissues as well as one normal breast and one salivary gland tissues were analysed using the Affymetrix (R) Gene Chip. Results: The expression of some miRNAs differed in the tumor tissues compared to their controls: the let-7b was overexpressed in salivary gland-derived adenoid cystic carcinoma, while decreased in breast-derived adenoid cystic carcinoma. In addition, the miR-24 was decreased in salivary gland-derived but overexpressed in breast-derived adenoid cystic carcinomas. The miR-181a-2* was only detected in salivary gland-derived adenoid cystic carcinomas. Conclusions: Through post-transcriptional regulation of the genes, the diverse expression of some miRNAs may partially explain the diverse clinical outcome of salivary gland-derived and breast-derived adenoid cystic carcinomas.

引用

页码：963 / 968

页数：6

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