MicroRNA-profiling in breast- and salivary gland-derived adenoid cystic carcinomas

被引:3
作者
Kiss, Orsolya [1 ]
Tokes, Anna-Maria [3 ]
Spisak, Sandor [2 ]
Szilagyi, Anna [4 ]
Lippai, Norbert [5 ]
Szasz, A. Marcell [1 ]
Kulka, Janina [1 ]
机构
[1] Semmelweis Egyet, Altalanos Orvostudomanyi Kar, Patol Intezet 2, Budapest, Hungary
[2] Semmelweis Egyet, Altalanos Orvostudomanyi Kar, Belgyogyaszati Klin 2, Budapest, Hungary
[3] Magyar Tudomanyos Akad Semmelweis Egyet, Daganatprogresszio Kutatocsoport, Budapest, Hungary
[4] Szent Gyorgy Korhaz, Szekesfeherver, Hungary
[5] Jasz Nagykun Szolnok Megyei Hetenyi Geza Korhaz, Szolnok, Hungary
关键词
adenoid cystic carcinoma; micro-RNA; breast; salivary gland; EXPRESSION PATTERNS; MYB; BIOMARKERS; INVASION; FUSION; HEAD;
D O I
10.1556/OH.2013.29643
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Introduction: Adenoid cystic carcinoma is a salivary gland-derived malignant tumor, but rarely it can originate from the breast, too. The salivary gland-derived form shows a very aggressive clinical outcome, while adenoid cystic carcinoma of the breast has mostly a very good prognosis. Aim: The aim of the authors was to compare the miRNA-expression profile of breast-and salivary gland-derived cases. Method: The miRNA-profiles of two salivary gland derived and two breast-derived adenoid cystic carcinoma tissues as well as one normal breast and one salivary gland tissues were analysed using the Affymetrix (R) Gene Chip. Results: The expression of some miRNAs differed in the tumor tissues compared to their controls: the let-7b was overexpressed in salivary gland-derived adenoid cystic carcinoma, while decreased in breast-derived adenoid cystic carcinoma. In addition, the miR-24 was decreased in salivary gland-derived but overexpressed in breast-derived adenoid cystic carcinomas. The miR-181a-2* was only detected in salivary gland-derived adenoid cystic carcinomas. Conclusions: Through post-transcriptional regulation of the genes, the diverse expression of some miRNAs may partially explain the diverse clinical outcome of salivary gland-derived and breast-derived adenoid cystic carcinomas.
引用
收藏
页码:963 / 968
页数:6
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