Photo-triggered Drug Delivery Systems for Neuron-related Applications

被引:9
|
作者
Li, Wei [1 ,2 ]
Lin, Jing [1 ]
Wang, Tianfu [1 ]
Huang, Peng [1 ]
机构
[1] Shenzhen Univ, Hlth Sci Ctr, Sch Biomed Engn,Lab Evolutionary Theranost, Guangdong Key Lab Biomed Measurements & Ultrasoun, Shenzhen 518060, Peoples R China
[2] Georgia Inst Technol, Sch Chem & Biomol Engn, Atlanta, GA 30332 USA
基金
中国国家自然科学基金;
关键词
Photo-triggered. drug delivery systems; neuron; microfluidic system; hydrogel; nanoneedles; liposome; optical tweezer; optogeneties; ALBUMIN-BASED NANOPARTICLES; CARBON NANOTUBES; OPTOGENETIC CONTROL; CAGED COMPOUNDS; REMOTE-CONTROL; SILICA NANOPARTICLES; OPTICAL TWEEZERS; NETWORK ACTIVITY; BRAIN DELIVERY; GENE DELIVERY;
D O I
10.2174/0929867325666180622121801
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The development of materials, chemistry and genetics has created a great number of systems for delivering antibiotics, neuropeptides or other drugs to neurons in neuroscience research, and has also provided important and powerful tools in neuron-related applications. Although these drug delivery systems can facilitate the advancement of neuroscience studies, they still have limited applications due to various drawbacks, such as difficulty in controlling delivery molecules or drugs to the target region, and trouble of releasing them in predictable manners. The combination of optics and drug delivery systems has great potentials to address these issues and deliver molecules or drugs to the nervous system with extraordinary spatiotemporal selectivity triggered by light. In this review, we will introduce the development of photo-triggered drug delivery systems in neuroscience research and their neuron-related applications including regulatinv, neural activities, treating neural diseases and inducing nerve regenerations.
引用
收藏
页码:1406 / 1422
页数:17
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