Factors Associated with Visceral Leishmaniasis in the Americas: A Systematic Review and Meta-Analysis

被引:106
作者
Belo, Vinicius Silva [1 ]
Werneck, Guilherme Loureiro [2 ]
Barbosa, David Soeiro [1 ]
Simoes, Taynana Cesar [3 ]
Leandro Nascimento, Bruno Warlley [4 ]
da Silva, Eduardo Sergio [5 ]
Struchiner, Claudio Jose [1 ]
机构
[1] Fundacao Oswaldo Cruz Rio de Janeiro, Escola Nacl Saude Publ Sergio Arouca, Dept Endemias Samuel Pessoa, Rio De Janeiro, Brazil
[2] Univ Estado Rio de Janeiro, Inst Med Social, Dept Epidemiol, BR-20550011 Rio De Janeiro, Brazil
[3] Fundacao Oswaldo Cruz Rio de Janeiro, Escola Nacl Saude Publ Sergio Arouca, Dept Epidemiol & Metodos Quantitat Saude, Rio De Janeiro, Brazil
[4] Fundacao Oswaldo Cruz FIOCRUZ, Ctr Pesquisas Rene Rachou, Ctr Referencia Nacl & Int Flebotomineos, Belo Horizonte, MG, Brazil
[5] Univ Fed Sao Joao del Rei, Divinopolis, MG, Brazil
关键词
RISK-FACTORS; CHAGASI INFECTION; URBAN AREA; ASYMPTOMATIC INFECTION; LUTZOMYIA-LONGIPALPIS; IMMUNE-RESPONSE; BELO-HORIZONTE; RURAL FOCUS; SAND FLIES; OLD FOCUS;
D O I
10.1371/journal.pntd.0002182
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Background: Still today, more than 30 years after the beginning of the process of visceral leishmaniasis' urbanization, there is little knowledge about the risk factors for its occurrence, despite their relevance to the control and understanding of disease dynamics. The present study is the first systematic review with meta-analysis about factors associated with Leishmania infantum infection in humans in the Americas. Methods and Findings: After searching different databases, consultations to the reference lists of articles and to experts in the field, 51 studies were reviewed. Theoretical discussions or meta-analysis of p-values or of effect sizes were used to pool information about each variable. The Q test and the I-2 statistic were used to assess heterogeneities among the studies. Male sex was associated with visceral leishmaniasis in studies which used the leishmanin skin test for diagnosis and in those where the outcome was the clinical disease; the opposite occurred when serological diagnosis was applied. Younger individuals were less frequently infected than adults, but were more prone to illness. Although with different levels of evidence and of heterogeneity, the presence of dogs at home, higher dog seropositivity in nearby areas, lower socioeconomic status and highly vegetated areas were associated with L. infantum infection. This was not noticed for the presence of chickens in the house and with nutritional status. Susceptibilities to bias and limitations in the analysis and in the description of results were often identified in the studies analyzed. Conclusions: Results showed the existence of consistent patterns for some of the factors analyzed and should be taken into account in developing more effective and well-targeted control measures. Studies must be conducted in new areas of the continent, with improved methodological quality and prioritizing the investigation of the patterns identified and their causes, as well as variables for which knowledge is poor.
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页数:12
相关论文
共 92 条
[1]   Role of the domestic chicken (Gallus gallus) in the epidemiology of urban visceral leishmaniasis in Brazil [J].
Alexander, B ;
de Carvalho, RL ;
McCallum, H ;
Pereira, MH .
EMERGING INFECTIOUS DISEASES, 2002, 8 (12) :1480-1485
[2]   Leishmaniasis and poverty [J].
Alvar, Jorge ;
Yactayo, Sergio ;
Bern, Caryn .
TRENDS IN PARASITOLOGY, 2006, 22 (12) :552-557
[3]   Leishmaniasis Worldwide and Global Estimates of Its Incidence [J].
Alvar, Jorge ;
Velez, Ivan D. ;
Bern, Caryn ;
Herrero, Merce ;
Desjeux, Philippe ;
Cano, Jorge ;
Jannin, Jean ;
den Boer, Margriet .
PLOS ONE, 2012, 7 (05)
[4]   Risk Factors for Death in Children with Visceral Leishmaniasis [J].
Alves de Queiroz Sampaio, Marcia Jaqueline ;
Cavalcanti, Nara Vasconcelos ;
Bezerra Alves, Joao Guilherme ;
Costa Fernandes Filho, Mario Jorge ;
Correia, Jailson B. .
PLOS NEGLECTED TROPICAL DISEASES, 2010, 4 (11)
[5]   Assessment of knowledge and preventive attitudes concerning visceral leishmaniasis in Belo Horizonte, Minas Gerais State, Brazil [J].
Antunes Borges, Barbara Kellen ;
da Silva, Jose Ailton ;
Amaral Haddad, Joao Paulo ;
Moreira, Elvio Carlos ;
de Magalhaes, Danielle Ferreira ;
Lopes Ribeiro, Leticia Mendonca ;
Pires Fiuza, Vanessa de Oliveira .
CADERNOS DE SAUDE PUBLICA, 2008, 24 (04) :777-784
[6]  
Araujo VEM, 2011, THESIS UFMG BELO HOR
[7]   A PROSPECTIVE-STUDY OF VISCERAL LEISHMANIASIS IN AN ENDEMIC AREA OF BRAZIL [J].
BADARO, R ;
JONES, TC ;
LORENCO, R ;
CERF, BJ ;
SAMPAIO, D ;
CARVALHO, EM ;
ROCHA, H ;
TEIXEIRA, R ;
JOHNSON, WD .
JOURNAL OF INFECTIOUS DISEASES, 1986, 154 (04) :639-649
[8]   Human asymptomatic infection in visceral leishmaniasis: A Seroprevalence study in an urban area of low endemicity. Preliminary results [J].
Barao, Sandra C. ;
Camargo-Neves, Vera L. de Fonseca ;
Resende, Mariangela R. ;
da Silva, Luiz J. .
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2007, 77 (06) :1051-1053
[9]  
Bavia M. E., 2005, Parassitologia (Rome), V47, P165
[10]   Presence of Lutzomyia evansi, a vector of American visceral leishmaniasis, in an urban area of the Colombian Caribbean coast [J].
Bejarano, EE ;
Uribe, S ;
Rojas, W ;
Vélez, ID .
TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 2001, 95 (01) :27-28