The Flavonoid Quercetin Inhibits Pancreatic Cancer Growth In Vitro and In Vivo

被引：106

作者：

Angst, Eliane ^{[1
,2
,3
]}

Park, Jenny L. ^{[1
,2
]}

Moro, Aune ^{[1
,2
]}

Lu, Qing-Yi ^{[2
]}

Lu, Xuyang ^{[2
,4
]}

Li, Gang ^{[2
,4
]}

King, Jonathan ^{[1
,2
]}

Chen, Monica ^{[1
,2
]}

Reber, Howard A. ^{[1
,2
]}

Go, Vay Liang W. ^{[2
]}

Eibl, Guido ^{[1
,2
]}

Hines, Oscar J. ^{[1
,2
]}

机构：

[1] Univ Calif Los Angeles, David Geffen Sch Med, Dept Surg, Hirshberg Labs Pancreat Canc Res, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, David Geffen Sch Med, UCLA Ctr Excellence Pancreat Dis, Los Angeles, CA 90095 USA

[3] Univ Bern, Inselspital, CH-3010 Bern, Switzerland

[4] Univ Calif Los Angeles, Sch Publ Hlth, Dept Biostat, Los Angeles, CA 90095 USA

来源：

PANCREAS | 2013年 / 42卷 / 02期

基金：

瑞士国家科学基金会; 美国国家卫生研究院;

关键词：

pancreatic cancer; apoptosis; quercetin; orthotopic animal model; bioluminescence; APOPTOSIS; POLYPHENOLS; PREVENTION; AUTOPHAGY; PATHWAYS; HEALTH; AGENTS;

D O I：

10.1097/MPA.0b013e318264ccae

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Objectives: The flavonoid quercetin holds promise as an antitumor agent in several preclinical animal models. However, the efficacy of oral administration of quercetin in a pancreatic cancer mouse model is unknown. Methods: The antiproliferative effects of quercetin alone or in combination with gemcitabine were tested in 2 human pancreatic cancer cell lines using cell count and MTT assays. Apoptosis was evaluated by flow cytometry. Tumor growth in vivo was investigated in an orthotopic pancreatic cancer animal model using bioluminescence. Quercetin was administered orally in the diet. Results: Quercetin inhibited the growth of pancreatic cancer cell lines, which was caused by an induction of apoptosis. In addition, dietary supplementation of quercetin attenuated the growth of orthotopically transplanted pancreatic xenografts. The combination of gemcitabine and quercetin had no additional effect compared with quercetin alone. In vivo quercetin caused significant apoptosis and reduced tumor cell proliferation. Conclusions: Our data provide evidence that oral administration of quercetin was capable of inhibiting growth of orthotopic pancreatic tumors in a nude mouse model. These data suggest a possible benefit of quercetin in patients with pancreatic cancer.

引用

页码：223 / 229

页数：7

共 34 条

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