Selective Cytotoxic Effect of Dorycnium pentaphyllum Extract on Human Breast, Liver, and Lung Cancer Cells

被引:7
作者
Demir, Selim [1 ]
Turan, Ibrahim [2 ]
Misir, Sema [3 ]
Aliyazicioglu, Yuksel [4 ]
机构
[1] Karadeniz Tech Univ, Dept Nutr & Dietet, Fac Hlth Sci, TR-61080 Trabzon, Turkey
[2] Gumushane Univ, Fac Engn & Nat Sci, Dept Genet & Bioengn, TR-29100 Gumushane, Turkey
[3] Sivas Cumhuriyet Univ, Dept Biochem, Fac Pharm, TR-58100 Sivas, Turkey
[4] Karadeniz Tech Univ, Dept Med Biochem, Fac Med, TR-61080 Trabzon, Turkey
来源
KSU TARIM VE DOGA DERGISI-KSU JOURNAL OF AGRICULTURE AND NATURE | 2019年 / 22卷 / 03期
关键词
Antioxidant activity; Cancer; Cytotoxicity; Dorycnium pentaphyllum; Fabaceae; TURKISH PROPOLIS; CYCLE ARREST; HUMAN COLON; FABACEAE; ANTIOXIDANT; APOPTOSIS; ANTIBACTERIAL; PLANTS;
D O I
10.18016/ksutarimdoga.vi.497868
中图分类号
S [农业科学];
学科分类号
09 ;
摘要
Although some studies have evaluated the cytotoxic activity of different Fabaceae species, there has been only limited research into the cytotoxic effect of Dorycnium pentaphyllum. The purpose of this study was to determine the antioxidant properties and cytotoxic effect of D. pentaphyllum extract on various human cancer cells. The total phenolic content (TPC) of the extract was determined using colorimetric method. The cytotoxic effect of the extract on human lung (A549), liver (HepG2), and breast (MCF-7) cancer cells and a normal human fibroblast cells was assessed using the MTT assay. TPC value of extract was found as 140.3 +/- 1.1 mg gallic acid equivalent per g sample. Extract showed selective cytotoxicity on all studied cancer cells compared to normal fibroblast cells, and the IC50 values of the extract in the cancer cells range from 100.4 to 298.5 mu g/mL. This is the first study to reveal the cytotoxic effect of D. pentaphyllum extract on cancer cell lines. Phytomedical applications of D. pentaphyllum may represent promising approaches in the treatment of cancer.
引用
收藏
页码:473 / 479
页数:7
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