Viridicatumtoxin B, a new anti-MRSA agent from Penicillum sp FR11

被引：32

作者：

Zheng, Chang-Ji ^{[1
]}

Yu, Hyung-Eun ^{[1
]}

Kim, Eun-Hee ^{[2
]}

Kim, Won-Gon ^{[1
]}

机构：

[1] Korea Res Inst Biosci & Biotechnol, Taejon 305806, South Korea

[2] Korea Basic Sci Inst, Magnet Resonance Team, Cheongwon 363883, Chungbuk, South Korea

来源：

JOURNAL OF ANTIBIOTICS | 2008年 / 61卷 / 10期

关键词：

viridicatumtoxin B; tetracycline; Penicillium; antibacterial; MRSA;

D O I：

10.1038/ja.2008.84

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A new tetracycline-type antibiotic named viridicatumtoxin B along with the known compound viridicatumtoxin has been isolated from the mycelium of liquid fermentation cultures of Penicillium sp. FR11. The structure of viridicatumtoxin B was determined on the basis of MS and NMR data. Viridicatumtoxin B inhibited the growth of Staphylococcus aureus including methicillin-resistant S. aureus and quinolone-resistant S. aureus with MIC (mu g/ml) of 0.5, which is similar with that of vancomycin, but 8 similar to 64 times higher activity than that of tetracycline.

引用

页码：633 / 637

页数：5

共 5 条

[1] VIRIDICATUMTOXIN, A NEW MYCOTOXIN FROM PENICILLIUM-VIRIDICATUM WESTLING
HUTCHISO.RD
STEYN, PS
VANRENSB.SJ
[J]. TOXICOLOGY AND APPLIED PHARMACOLOGY, 1973, 24 (03) : 507 - 509
[2] Antibacterial resistance worldwide: causes, challenges and responses
Levy, SB
Marshall, B
[J]. NATURE MEDICINE, 2004, 10 (12) : S122 - S129
[3] Pfeltz R. F., 2004, Current Drug Targets - Infectious Disorders, V4, P273, DOI 10.2174/1568005043340470
[4] MICROBIAL TRANSFORMATIONS OF NATURAL ANTI-TUMOR AGENTS .20. GLUCOSYLATION OF VIRIDICATUMTOXIN
RAJU, MS
WU, GS
GARD, A
ROSAZZA, JP
[J]. JOURNAL OF NATURAL PRODUCTS, 1982, 45 (03): : 321 - 327
[5] THE STRUCTURE AND ABSOLUTE-CONFIGURATION OF VIRIDICATUMTOXIN - 2'S-(2'-ALPHA,7'A-BETA,11'A-BETA,12'-BETA)-7',7'A,8',11',11'A,12'-HEXAHYDRO-5',6',7'A,10',11'A,12'-HEXAHYDROXY-3'-METHOXY-2,6,6-TRIMETHYL-7',8'-DIOXOSPIRO[2-CYCLOHEXENE-1,2'(1'H)-CYCLOPENTA[DE]NAPHTHACENE]-9'-CARBOXAMIDE METHANOLATE
SILVERTON, JV
KABUTO, C
AKIYAMA, T
[J]. ACTA CRYSTALLOGRAPHICA SECTION B-STRUCTURAL SCIENCE, 1982, 38 (DEC): : 3032 - 3037

← 1 →