Valeriana officinalis Extracts Ameliorate Neuronal Damage by Suppressing Lipid Peroxidation in the Gerbil Hippocampus Following Transient Cerebral Ischemia

被引：17

作者：

Yoo, Dae Young ^{[1
]}

Jung, Hyo Young ^{[1
]}

Nam, Sung Min ^{[1
]}

Kim, Jong Whi ^{[1
]}

Choi, Jung Hoon ^{[2
]}

Kwak, Youn-Gil ^{[3
]}

Yoo, Miyoung ^{[4
]}

Lee, Sanghee ^{[4
]}

Yoon, Yeo Sung ^{[1
]}

Hwang, In Koo ^{[1
]}

机构：

[1] Seoul Natl Univ, Res Inst Vet Sci, Dept Anat & Cell Biol, Coll Vet Med, Seoul 151742, South Korea

[2] Kangwon Natl Univ, Dept Anat, Coll Vet Med, Chunchon, South Korea

[3] Nat F&P Co Ltd, Cent Res Ctr, Cheongwon, South Korea

[4] Korea Food Res Inst, Food Anal Ctr, Songnam, South Korea

来源：

JOURNAL OF MEDICINAL FOOD | 2015年 / 18卷 / 06期

关键词：

Valeriana officinalis; lipid peroxidation; gerbil ischemia; hippocampus; NF-KAPPA-B; INFLAMMATORY MECHANISMS; FOREBRAIN ISCHEMIA; VALERENIC ACID; BRAIN; DEATH; MEMORY; PATHOPHYSIOLOGY; ACTIVATION; MODEL;

D O I：

10.1089/jmf.2014.3295

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

As a medicinal plant, the roots of Valeriana officinalis have been used as a sedative and tranquilizer. In the present study, we evaluated the neuroprotective effects of valerian root extracts (VE) on the hippocampal CA1 region of gerbils after 5 min of transient cerebral ischemia. Gerbils were administered VE orally once a day for 3 weeks, subjected to ischemia/reperfusion injury, and continued on VE for 3 weeks. The administration of 100 mg/kg VE (VE100 group) significantly reduced the ischemia-induced spontaneous motor hyperactivity 1 day after ischemia/reperfusion. Four days after ischemia/reperfusion, animals treated with VE showed abundant cresyl violet-positive neurons in the hippocampal CA1 region when compared to the vehicle or 25 mg/kg VE-treated groups. In addition, the VE treatment markedly decreased microglial activation in the hippocampal CA1 region 4 days after ischemia. Compared to the other groups, the VE100 group showed the lowest level of lipid peroxidation during the first 24 h after ischemia/reperfusion. In summary, the findings in this study suggest that pretreatment with VE has protective effects against ischemic injury in the hippocampal pyramidal neurons by decreasing microglial activation and lipid peroxidation.

引用

页码：642 / 647

页数：6

共 43 条

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