Practical synthesis of novel purine analogues as Hsp90 inhibitors

被引：19

作者：

Semeraro, Teresa ^{[1
]}

Mugnaini, Claudia ^{[1
]}

Manetti, Fabrizio ^{[1
]}

Pasquini, Serena ^{[1
]}

Corelli, Federico ^{[1
]}

机构：

[1] Univ Siena, Dipartimento Farmaco Chim Tenol, I-53100 Siena, Italy

来源：

TETRAHEDRON | 2008年 / 64卷 / 49期

关键词：

D O I：

10.1016/j.tet.2008.09.030

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The development of a straightforward synthesis of 4-amino-6-benzyl-6H-pyrrolo[3,4-d]pyrimidine and 7-amino-2-benzyl-2H-pyrazolo[4,3-d]primidine derivatives allowed for the preparation of a small family of potential Hsp90 inhibitors. Some of the newly synthesized compounds showed Hsp90 inhibitory activity in preliminary biological assays. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：11249 / 11255

页数：7

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