Functional genetic variants in pre-miR-146a and 196a2 genes are associated with risk of lung cancer in North Indians

被引：36
|
作者：
Sodhi, Kushaldeep Kaur [1 ]
Bahl, Charu [1 ]
Singh, Navneet [2 ]
Behera, Digamber [2 ]
Sharma, Siddharth [1 ]
机构：
[1] Thapar Univ, Dept Biotechnol, Patiala 147002, Punjab, India
[2] Post Grad Inst Educ & Med Res PGIMER, Sect 14, Dept Pulm Med, Chandigarh, India
来源：
FUTURE ONCOLOGY | 2015年 / 11卷 / 15期
关键词：
genotype; lung cancer; miR-146a; miR-196a2; single nucleotide polymorphism; HEPATOCELLULAR-CARCINOMA; CHINESE POPULATION; GASTRIC-CANCER; MICRORNA POLYMORPHISMS; COLORECTAL-CANCER; KOREAN POPULATION; CELL CARCINOMA; MIR-146A GENE; SUSCEPTIBILITY; EXPRESSION;
D O I：
10.2217/fon.15.143
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Objective: To find the association of two pre-miRNA polymorphisms with risk of lung cancer in North Indians. Materials & methods: Genotyping of 250 cases and 255 controls for miR-146a and miR-196a2 using PCR-RFLP. Results: Heterozygous subjects showed a risk toward lung cancer (LC), especially for adenocarcinoma (OR: 1.82; 95% CI: 1.04-3.20; p = 0.03) in miR-146a gene. TT genotype for miR-196a2 gene also showed 3.2-fold risk toward LC and the risk was fivefold higher for squamous cell carcinoma. Survival rate was significantly lower in subjects with TT genotype as compared with the CC genotype in miR-196a2.Conclusion: Both the single nucleotide polymorphism variants showed a positive association toward risk of lung cancer.
引用
收藏
页码：2159 / 2173
页数：15
相关论文
共 50 条
  • [41] Association of genetic variants in soy isoflavones metabolism-related genes with decreased lung cancer risk
    Xie, Dongming
    Pan, Yujie
    Chen, Jinbin
    Mao, Chun
    Li, Zhi
    Qiu, Fuman
    Yang, Lei
    Deng, Yibin
    Lu, Jiachun
    GENE, 2024, 927
  • [42] A COMMON POLYMORPHISM IN PRE-MICRORNA-146A IS ASSOCIATED WITH LUNG CANCER RISK IN A KOREAN POPULATION
    Jeon, Hyo-Sung
    Lee, Shin Yup
    Kim, Mi Young
    Choi, Keum Ju
    Jeong, Ji Yun
    Hong, Mi Jung
    Jang, Ji-Ae
    Choi, Jin Eun
    Yoo, Seung Soo
    Lee, Jaehee
    Lee, Eung Bae
    Cha, Seung Ick
    Kim, Chang Ho
    Park, Jae Yong
    JOURNAL OF THORACIC ONCOLOGY, 2013, 8 : S440 - S440
  • [43] Association of SNPs in miR-146a, miR-196a2, and miR-499 with the risk of endometrial/ovarian cancer
    Liu, Xiaoyan
    Xu, Beihui
    Li, Shujin
    Zhang, Bin
    Mao, Peimin
    Qian, Beibei
    Guo, Lin
    Ni, Peihua
    ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2015, 47 (07) : 564 - 566
  • [44] Genetic evaluation of the variants using MassARRAY in non-small cell lung cancer among North Indians
    Bhat, Gh Rasool
    Sethi, Itty
    Bhat, Amrita
    Verma, Sonali
    Bakshi, Divya
    Sharma, Bhanu
    Nazir, Muddasser
    Dar, Khursheed A.
    Abrol, Deepak
    Shah, Ruchi
    Kumar, Rakesh
    SCIENTIFIC REPORTS, 2021, 11 (01)
  • [45] A Functional Genetic Variant in microRNA-196a2 Is Associated with Increased Susceptiblility of Lung Cancer in Chinese
    Tian, Tian
    Shu, Yongqian
    Chen, Jiaping
    Hu, Zhibin
    Xu, Lin
    Jin, Guangfu
    Liang, Jie
    Liu, Ping
    Zhou, Xiaoyi
    Miao, Ruifen
    Ma, Hongxia
    Chen, Yijiang
    Shen, Hongbing
    CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2009, 18 (04) : 1183 - 1187
  • [46] The Association of Common Functional Polymorphisms in Mir-146a and Mir-196a2 and Hepatocellular Carcinoma Risk Evidence from a Meta-Analysis
    Peng, Qiliu
    Li, Shan
    Lao, Xianjun
    Chen, Zhiping
    Li, Ruolin
    Deng, Yan
    Qin, Xue
    MEDICINE, 2014, 93 (29) : e252
  • [47] A genetic variant in microRNA-196a2 is associated with increased cancer risk: a meta-analysis
    Wang, Feng
    Ma, Yan-Lei
    Zhang, Peng
    Yang, Jian-Jun
    Chen, Hong-Qi
    Liu, Zhi-Hua
    Peng, Jia-Yuan
    Zhou, Yu-Kun
    Qin, Huan-Long
    MOLECULAR BIOLOGY REPORTS, 2012, 39 (01) : 269 - 275
  • [48] Effects of common polymorphisms in miR-146a and miR-196a2 on lung cancer susceptibility: a meta-analysis
    Ren, Yan-Gang
    Zhou, Xiao-Ming
    Cui, Zhi-Gang
    Hou, Gang
    JOURNAL OF THORACIC DISEASE, 2016, 8 (06) : 1297 - 1305
  • [49] Genetic variants in the plasminogen activator inhibitor-1 gene are associated with an increased risk of radiation pneumonitis in lung cancer patients
    Liu, Bo
    Tang, Yang
    Yi, Minxiao
    Liu, Qingxu
    Xiong, Huihua
    Hu, Guangyuan
    Yuan, Xianglin
    CANCER MEDICINE, 2017, 6 (03): : 681 - 688
  • [50] A Functional Polymorphism in MIR196A2 Is Associated with Risk and Progression of Nasopharyngeal Carcinoma in the Chinese Population
    Li, Peiyao
    Yan, Hongbo
    Zhang, Hongxing
    Yu, Lixia
    Wang, Zhifu
    Zhai, Yun
    Xia, Xia
    Zhang, Jiye
    Zhang, Yang
    Ma, Fuchao
    Huang, Wenfeng
    Cai, Mi
    Cui, Ying
    He, Fuchu
    Zhou, Gangqiao
    GENETIC TESTING AND MOLECULAR BIOMARKERS, 2014, 18 (03) : 149 - 155
12345