Functional genetic variants in pre-miR-146a and 196a2 genes are associated with risk of lung cancer in North Indians

被引：35

作者：

Sodhi, Kushaldeep Kaur ^{[1
]}

Bahl, Charu ^{[1
]}

Singh, Navneet ^{[2
]}

Behera, Digamber ^{[2
]}

Sharma, Siddharth ^{[1
]}

机构：

[1] Thapar Univ, Dept Biotechnol, Patiala 147002, Punjab, India

[2] Post Grad Inst Educ & Med Res PGIMER, Sect 14, Dept Pulm Med, Chandigarh, India

来源：

FUTURE ONCOLOGY | 2015年 / 11卷 / 15期

关键词：

genotype; lung cancer; miR-146a; miR-196a2; single nucleotide polymorphism; HEPATOCELLULAR-CARCINOMA; CHINESE POPULATION; GASTRIC-CANCER; MICRORNA POLYMORPHISMS; COLORECTAL-CANCER; KOREAN POPULATION; CELL CARCINOMA; MIR-146A GENE; SUSCEPTIBILITY; EXPRESSION;

D O I：

10.2217/fon.15.143

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Objective: To find the association of two pre-miRNA polymorphisms with risk of lung cancer in North Indians. Materials & methods: Genotyping of 250 cases and 255 controls for miR-146a and miR-196a2 using PCR-RFLP. Results: Heterozygous subjects showed a risk toward lung cancer (LC), especially for adenocarcinoma (OR: 1.82; 95% CI: 1.04-3.20; p = 0.03) in miR-146a gene. TT genotype for miR-196a2 gene also showed 3.2-fold risk toward LC and the risk was fivefold higher for squamous cell carcinoma. Survival rate was significantly lower in subjects with TT genotype as compared with the CC genotype in miR-196a2.Conclusion: Both the single nucleotide polymorphism variants showed a positive association toward risk of lung cancer.

引用

页码：2159 / 2173

页数：15

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