Life in the human stomach: persistence strategies of the bacterial pathogen Helicobacter pylori

被引：479

作者：

Salama, Nina R. ^{[1
]}

Hartung, Mara L. ^{[2
]}

Mueller, Anne ^{[2
]}

机构：

[1] Fred Hutchinson Canc Res Ctr, Div Human Biol, Seattle, WA 98109 USA

[2] Univ Zurich, Inst Mol Canc Res, CH-8057 Zurich, Switzerland

来源：

NATURE REVIEWS MICROBIOLOGY | 2013年 / 11卷 / 06期

基金：

美国国家卫生研究院; 瑞士国家科学基金会;

关键词：

GAMMA-GLUTAMYL-TRANSPEPTIDASE; T-CELL PROLIFERATION; IV SECRETION; VACUOLATING CYTOTOXIN; GASTRIC-CANCER; DENDRITIC CELLS; EXPERIMENTAL-INFECTION; IMMUNE-RESPONSE; PHASE VARIATION; HOST-CELLS;

D O I：

10.1038/nrmicro3016

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The bacterial pathogen Helicobacter pylori has co-evolved with humans and colonizes approximately 50% of the human population, but only causes overt gastric disease in a subset of infected hosts. In this Review, we discuss the pathogenesis of H. pylori and the mechanisms it uses to promote persistent colonization of the gastric mucosa, with a focus on recent insights into the role of the virulence factors vacuolating cytotoxin (VacA), cytotoxin-associated gene A (CagA) and CagL. We also describe the immunobiology of H. pylori infection and highlight how this bacterium manipulates the innate and adaptive immune systems of the host to promote its own persistence.

引用

页码：385 / 399

页数：15

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