Brain Imaging in Pediatric Obsessive-Compulsive Disorder

被引：49

作者：

MacMaster, Frank P. ^{[1
]}

O'Neill, Joseph ^{[2
]}

Rosenberg, David R. ^{[1
]}

机构：

[1] Wayne State Univ, Dept Psychiat & Behav Neurosci, Detroit, MI 48202 USA

[2] Univ Calif Los Angeles, Semel Inst Neurosci, Div Child & Adolescent Psychiat, Los Angeles, CA 90024 USA

来源：

JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY | 2008年 / 47卷 / 11期

关键词：

glutamate; gene; obsessive-compulsive disorder; pediatric; striatum;

D O I：

10.1097/CHI.0b013e318185d2be

中图分类号：

B844 [发展心理学（人类心理学）];

学科分类号：

040202 ;

摘要：

To review progress in understanding pediatric obsessive-compulsive disorder (OCD). The focus is on the frontal-striatal-thalamic model of OCD, neurobiological and genetic studies of the disorder, and their influence on recent advances in treatment. Method: Computerized literature searches were conducted with the key words "obsessive-compulsive disorder" in conjunction with "pediatric," "genetics," and "imaging." Results: Neuroimaging studies find evidence to support the frontal-striatal-thalamic model. Genetic and neurochemical studies also implicate glutamate in the pathological finding of OCD. This has led to the application of glutamate-modulating agents to treat OCD. Conclusions: Studies of pediatric OCD have led to a refined frontal-striatal-thalamic model of pathogenesis and are having an evidence-based impact on treatment. Despite this progress, fully explanatory models are still needed that would allow for accurate prognosis and the development of targeted and efficacious treatments. J. Am. Acad. Child Adolesc. Psychiatry, 2008; 47(11):1262-1272.

引用

页码：1262 / 1272

页数：11

共 108 条

[1] CHRONIC FLUOXETINE TREATMENT REDUCES HYPOTHALAMIC VASOPRESSIN SECRETION INVITRO [J].

ALTEMUS, M ;

CIZZA, G ;

GOLD, PW .

BRAIN RESEARCH, 1992, 593 (02) :311-313

[2]

*AM PSYCH ASS, 1994, DIAGN STAT MAN PSYCH

[3] Increased number of subcortical hyperintensities on MRI in children and adolescents with Tourette's syndrome, obsessive-compulsive disorder, and attention deficit hyperactivity disorder [J].

Amat, Jose A. ;

Bronen, Richard A. ;

Saluja, Sanjay ;

Sato, Noriko ;

Zhu, Hongtu ;

Gorman, Daniel A. ;

Royal, Jason ;

Peterson, Bradley S. .

AMERICAN JOURNAL OF PSYCHIATRY, 2006, 163 (06) :1106-1108

[4] Neuronal glutathione deficiency and age-dependent neurodegeneration in the EAAC1 deficient mouse [J].

Aoyama, K ;

Suh, SW ;

Hamby, AM ;

Liu, JL ;

Chan, WY ;

Chen, YM ;

Swanson, RA .

NATURE NEUROSCIENCE, 2006, 9 (01) :119-126

[5] Glutamate transporter gene SLC1A1 associated with obsessive-compulsive disorder [J].

Arnold, Paul Daniel ;

Sicard, Tricia ;

Burroughs, Eliza ;

Richter, Margaret A. ;

Kennedy, James L. .

ARCHIVES OF GENERAL PSYCHIATRY, 2006, 63 (07) :769-776

[6] Association of a glutamate (NMDA) subunit receptor gene (GRIN2B) with obsessive-compulsive disorder: a preliminary study [J].

Arnold, PD ;

Rosenberg, DR ;

Mundo, E ;

Tharmalingam, S ;

Kennedy, JL ;

Richter, MA .

PSYCHOPHARMACOLOGY, 2004, 174 (04) :530-538

[7] Single-voxel proton MRS of the human brain at 1.5T and 3.0T [J].

Barker, PB ;

Hearshen, DO ;

Boska, MD .

MAGNETIC RESONANCE IN MEDICINE, 2001, 45 (05) :765-769

[8] Changes in NMDA-receptor gene expression are associated with neurotoxicity induced neonatally by glutamate in the rat brain [J].

Beas-Zárate, C ;

Rivera-Huizar, SV ;

Martinez-Contreras, A ;

Feria-Velasco, A ;

Armendariz-Borunda, J .

NEUROCHEMISTRY INTERNATIONAL, 2001, 39 (01) :1-10

[9]

Beers SR, 1999, AM J PSYCHIAT, V156, P777

[10] Neurochemical analyses in pediatric obsessive-compulsive disorder in patients treated with cognitive-behavioral therapy [J].

Benazon, NR ;

Moore, GJ ;

Rosenberg, DR .

JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY, 2003, 42 (11) :1279-1285

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