Tribenzyltin carboxylates as anticancer drug candidates: Effect on the cytotoxicity, motility and invasiveness of breast cancer cell lines

被引：28

作者：

Anasamy, Theebaa ^{[1
]}

Thy, Chun Keng ^{[2
]}

Lo, Kong Mun ^{[2
,3
]}

Chee, Chin Fei ^{[2
]}

Yeap, Swee Keong ^{[4
]}

Kamalidehghan, Behnam ^{[5
,6
]}

Chung, Lip Yong ^{[1
]}

机构：

[1] Univ Malaya, Dept Pharm, Fac Med, Kuala Lumpur 50603, Malaysia

[2] Univ Malaya, Dept Chem, Fac Sci, Kuala Lumpur 50603, Malaysia

[3] Sunway Univ, Res Ctr Crystalline Mat, Petaling Jaya 47500, Selangor Darul, Malaysia

[4] Univ Putra Malaysia, Inst Biosci, Serdang 43400, Selangor Darul, Malaysia

[5] Shahid Beheshti Univ Med Sci, Sch Med, Dept Med Genet, Tehran 1983963113, Iran

[6] NIGEB, Med Genet Dept, Tehran 1497716316, Iran

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2017年 / 125卷

关键词：

Organotin complexes; Tribenzyltin carboxylates; Anticancer; Antimotility; Apoptosis; Breast cancer; PROTEASOME INHIBITORS; IN-VITRO; PYRROLIDINE DITHIOCARBAMATE; CASPASE ACTIVATION; ANTITUMOR-ACTIVITY; APOPTOSIS; COMPLEXES; TUMOR; FLUORINE; ASSAY;

D O I：

10.1016/j.ejmech.2016.09.061

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

This study seeks to investigate the relationship between the structural modification and bioactivity of a series of tribenzyltin complexes with different ligands and substitutions. Complexation with the N,N-diisopropylcarbamothioylsulfanylacetate or isonicotinate ligands enhanced the anticancer properties of tribenzyltin compounds via delayed cancer cell-cycle progression, caspase-dependent apoptosis induction, and significant reduction in cell motility, migration and invasion. Halogenation of the benzyl ring improved the anticancer effects of the tribenzyltin compounds with the N,N-diisopropylcarbamothioylsulfanylacetate ligand. These compounds also demonstrated far greater anticancer effects and selectivity than cisplatin and doxorubicin, which provides a rationale for their further development as anticancer agents. (C) 2016 Elsevier Masson SAS. All rights reserved.

引用

页码：770 / 783

页数：14

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[21] Morphological assessment of apoptosis [J].