A mammary gland adenomyoepithelioma in a C57BL/6 mouse

被引：2
作者：
Bauchet, Anne-Laure [2 ]
Elies, Laetitia [1 ]
Maliver, Pierre [1 ]
Fouque, Marie-Claude [1 ]
Balme, Emmanuelle [2 ]
Chateau-Joubert, Sophie [2 ]
Schorsch, Frederic [1 ]
Fontaine, Jean-Jacques [2 ]
机构：
[1] Bayer CropSci, Pathol Unit, F-06903 Sophia Antipolis, France
[2] Vet Sch Alfort, Dept Pathol, F-94704 Maisons Alfort, France
来源：
EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY | 2008年 / 60卷 / 4-5期
关键词：
mouse; C57BL/6; adenomyoepithelioma; complex mammary gland tumor; mammary gland;
D O I：
10.1016/j.etp.2008.02.008
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Mammary gland adenomyoepitheliomas are benign complex mammary gland tumors composed of neoplastic cells of epithelial and myoepithelial origins, described in many species (humans, dogs, cats, rats) and rarely in mice. We report here an adenomyoepithelioma in a C57BL/6 female mouse. Histologically, tubes and cords formed by neoplastic epithelial cells were separated by bundles of neoplastic myoepithelial cells in a clear and partially mucinous matrix. The tumor displayed characteristics of a benign neoplastic proliferation with a compressive growth pattern, and moderate cellular pleomorphism and mitotic index. At immunohistochemistry, the epithelial cells were strongly cytokeratin positive; the myoepithelial cells were weakly cytokeratin positive and strongly smooth muscle actin positive. This is to our knowledge, the first report or a mammary gland adenomyoepithelioma in a C57BL/6 mouse. (C) 2008 Elsevier GmbH. All rights reserved.
引用
收藏
页码：307 / 311
页数：5
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