Transferable mechanisms of quinolone resistance

被引：84
作者：
Ruiz, Joaquim [1 ]
Pons, Maria J. [1 ]
Gomes, Claudia [1 ]
机构：
[1] Univ Barcelona, Ctr Recerca Salut Int Barcelona CRESIB, Hosp Clin, Barcelona 08036, Spain
来源：
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS | 2012年 / 40卷 / 03期
关键词：
Quinolone resistance; Qnr; Qep; OqxAB; AAC(6 ')-Ib-cr; Natural transformation; 16S RIBOSOMAL-RNA; PENTAPEPTIDE REPEAT PROTEINS; MULTIDRUG EFFLUX PUMP; PLASMID-MEDIATED RESISTANCE; NALIDIXIC-ACID-RESISTANT; ESCHERICHIA-COLI; FLUOROQUINOLONE RESISTANCE; STENOTROPHOMONAS-MALTOPHILIA; ANTIMICROBIAL RESISTANCE; HYDROPHILIC FLUOROQUINOLONES;
D O I：
10.1016/j.ijantimicag.2012.02.011
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Quinolones were introduced into clinical practice in the late 1960s. Although quinolone resistance was described early, no transferable mechanism of quinolone resistance (TMQR) was confirmed until 1998. To date, five different TMQRs have been described in the literature, including target protection (Qnr), quinolone modification (AAC(6')-Ib-cr), plasmid-encoded efflux systems (e.g. QepA or OqxAB, amongst others), effect on bacterial growth rates and natural transformation. Although TMQRs usually only result in a slight increase in the minimum inhibitory concentrations of quinolones, they possess an additive effect and may facilitate the acquisition of full quinolone resistance. The emergence of new related genes may continue in the next years. (C) 2012 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.
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收藏
页码：196 / 203
页数：8
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