There's plenty of room at the forum: Potential risks and safety assessment of engineered nanomaterials

被引:27
作者
Fadeel, Bengt [1 ]
Kagan, Valerian [2 ]
Krug, Harald [3 ]
Shvedova, Anna [4 ,5 ]
Svartengren, Magnus [6 ,7 ]
Tran, Lang [8 ]
Wiklund, Lars [9 ,10 ]
机构
[1] Karolinska Inst, Inst Environm Med, Div Biochem Toxicol, Cell Death Res Grp, S-17177 Stockholm, Sweden
[2] Univ Pittsburgh, Ctr Free Rad & Antioxidant Hlth, Dept Environm & Occupat Hlth, Pittsburgh, PA USA
[3] Swiss Fed Labs Mat Testing & Res EMPA, Div Mat Sci & Technol, St Gallen, Switzerland
[4] NIOSH, Pathol & Physiol Res Branch, Hlth Effects Lab Div, Morgantown, WV USA
[5] W Virginia Univ, Dept Physiol & Pharmacol, Morgantown, WV 26506 USA
[6] Karolinska Univ Hosp, Stockholm Cty Council, Div Occupat & Environm Hlth, Stockholm, Sweden
[7] Karolinska Inst, Dept Publ Hlth Sci, Stockholm, Sweden
[8] Inst Occupat Med, Edinburgh EH8 9SV, Midlothian, Scotland
[9] Swedish Soc Toxicol SFT, Stockholm, Sweden
[10] Regulatory Safety Sci RegSafe, Stockholm, Sweden
关键词
Nanotoxicology; carbon nanotubes; inflammation; pulmonary exposure; risk assessment;
D O I
10.1080/17435390701565578
中图分类号
TB3 [工程材料学];
学科分类号
0805 ; 080502 ;
摘要
The celebrated physicist and Nobel laureate Richard Feynman was the first to predict the opportunities presented by the manipulation of matter at the level of individual atoms and molecules. Today, almost 50 years after his classic lecture on the wonders of the small world, the evolving nanotechnologies have the potential to bring about major changes in the lives of citizens. However, the very same properties that make engineered nanomaterials so promising from a technological perspective, such as their high degree of reactivity and the ability to cross biological barriers, could also make these novel materials harmful to human health and the environment. Therefore, exploitation of the full potential of the nanotechnologies requires close attention to safety issues. The 1st Nobel Forum mini-symposium on nanotoxicology was recently held in Stockholm, Sweden, and the program was devoted to the topic of definitions and standardization in nanotoxicological research, as well as nano-specific risk assessment and regulatory/legislative issues. Examples of recent and ongoing studies of carbon-based nanomaterials, including single-walled carbon nanotubes, using a wide range of in vitro and in vivo model systems were also presented. The current review will provide some highlights and conclusions from this exciting meeting.
引用
收藏
页码:73 / 84
页数:12
相关论文
共 65 条
  • [1] ANDERSEN HC, 1835, FAIRY TALES TOLD CHI
  • [2] [Anonymous], NAN NAN OPP UNC
  • [3] [Anonymous], 1960, ENG SCI, DOI [DOI 10.1109/84.128057, 10.1109/84.128057]
  • [4] [Anonymous], APPR EX METH ASS POT
  • [5] Ashwood P, 2007, EXP BIOL MED, V232, P107
  • [6] DNA nanomachines
    Bath, Jonathan
    Turberfield, Andrew J.
    [J]. NATURE NANOTECHNOLOGY, 2007, 2 (05) : 275 - 284
  • [7] Ultrafine particle deposition and clearance in the healthy and obstructed lung
    Brown, JS
    Zeman, KL
    Bennett, WD
    [J]. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2002, 166 (09) : 1240 - 1247
  • [8] Nanotechnological applications in medicine
    Caruthers, Shelton D.
    Wickline, Samuel A.
    Lanza, Gregory M.
    [J]. CURRENT OPINION IN BIOTECHNOLOGY, 2007, 18 (01) : 26 - 30
  • [9] Gold nanoparticles are taken up by human cells but do not cause acute cytotoxicity
    Connor, EE
    Mwamuka, J
    Gole, A
    Murphy, CJ
    Wyatt, MD
    [J]. SMALL, 2005, 1 (03) : 325 - 327
  • [10] Cullen RT, 2000, INHAL TOXICOL, V12, P1089