Asymmetric Hydrogenation of α,α′-Disubstituted Cycloketones through Dynamic Kinetic Resolution: An Efficient Construction of Chiral Diols with Three Contiguous Stereocenters

被引：79

作者：

Liu, Chong ^{[1
,2
]}

Xie, Jian-Hua ^{[1
,2
]}

Li, Ya-Li ^{[1
,2
]}

Chen, Ji-Qiang ^{[1
,2
]}

Zhou, Qi-Lin ^{[1
,2
]}

机构：

[1] Nankai Univ, State Key Lab, Tianjin 300071, Peoples R China

[2] Nankai Univ, Inst Elementoorgan Chem, Tianjin 300071, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 02期

基金：

中国国家自然科学基金;

关键词：

asymmetric hydrogenation; cycloketones; dynamic kinetic resolution; lycorane; ruthenium; BETA-ARYLOXY ALCOHOLS; ENANTIOSELECTIVE SYNTHESIS; CATALYTIC-HYDROGENATION; PHOSPHORUS LIGANDS; RUTHENIUM; ESTERS; KETONES; CYCLIZATION; REDUCTION; COMPLEXES;

D O I：

10.1002/anie.201207561

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Chiral diols with three contiguous stereocenters were synthesized by a highly enantioselective ruthenium-catalyzed asymmetric hydrogenation of racemic α,α′-disubstituted cycloketones involving dynamic kinetic resolution. This new catalytic asymmetric method provides a concise route to the alkaloid (+)-γ-lycorane. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：593 / 596

页数：4

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