Laser 3D micro/nanofabrication of polymers for tissue engineering applications

被引：48
作者：
Danilevicius, P. [1 ]
Rekstyte, S. [1 ]
Balciunas, E. [2 ]
Kraniauskas, A. [3 ]
Sirmenis, R. [3 ]
Baltriukiene, D. [2 ]
Bukelskiene, V. [2 ]
Gadonas, R. [1 ]
Sirvydis, V. [3 ]
Piskarskas, A. [1 ]
Malinauskas, M. [1 ]
机构：
[1] Vilnius Univ, Fac Phys, Dept Quantum Elect, LT-10223 Vilnius, Lithuania
[2] Vivarium, Inst Biochem, LT-08662 Vilnius, Lithuania
[3] Vilnius Univ Hosp Santariskiu Klin, Ctr Heart Surg, LT-08661 Vilnius, Lithuania
来源：
OPTICS AND LASER TECHNOLOGY | 2013年 / 45卷
关键词：
Femtosecond laser micro/nanofabrication; 3D artificial scaffolds; Tissue engineering; ELECTRON-BEAM LITHOGRAPHY; 2-PHOTON POLYMERIZATION; CELL-GROWTH; PORE-SIZE; SCAFFOLDS; FABRICATION; MICROFABRICATION; MATRIX; BONE;
D O I：
10.1016/j.optlastec.2012.05.038
中图分类号：
O43 [光学];
学科分类号：
070207 ; 0803 ;
摘要：
In this work, we applied a constructed multi-photon polymerization system based on diode-pumped solid state femtosecond Yb:KGW laser used as pulsed irradiation light source (300 fs, 1030 nm, 200 kHz) in combination with large area high sample translation velocity (up to 300 mm/s) linear motor-driven stages (100 x 100 x 50 mm(3)) designed for high resolution and throughput 3D micro/nanofabrication. It enables rapid prototyping out of most polymers up to cm in scale with submicrometer spatial resolution. This can be used for production of three-dimensional artificial polymeric scaffolds applied for cell growth and expansion experiments as well as tissue engineering. Biocompatibilities of different acrylate, hybrid organic-inorganic and biodegradable polymeric materials were evaluated experimentally in vitro. Various in size and form scaffolds of biocompatible photopolymers were successfully fabricated having intricate 3D geometry, thus demonstrating the potential of the applied method. Adult rabbit myogenic stem cell proliferation tests show artificial scaffolds to be applicable for biomedical practice. Additionally, a micromolding technique was used for a rapid multiplication of adequate laser manufactured structures. (c) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：518 / 524
页数：7
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