The Protective Effect of Polyphenols for Colorectal Cancer

被引：70

作者：

Ding, Sujuan ^{[1
]}

Xu, Sheng ^{[1
]}

Fang, Jun ^{[1
]}

Jiang, Hongmei ^{[1
]}

机构：

[1] Hunan Agr Univ, Coll Biosci & Biotechnol, Hunan Prov Engn Res Ctr Appl Microbial Resources, Changsha, Peoples R China

来源：

FRONTIERS IN IMMUNOLOGY | 2020年 / 11卷

基金：

中国国家自然科学基金;

关键词：

polyphenols; colorectal cancer; intestinal inflammation; epigenetics; microbe; MOLECULAR-MECHANISMS; DIETARY POLYPHENOLS; INFLAMMATORY RESPONSE; TEA POLYPHENOLS; GENE-EXPRESSION; HUMAN COLON; RESVERATROL; TARGETS; CELLS; MICROBIOTA;

D O I：

10.3389/fimmu.2020.01407

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Colorectal cancer (CRC) is one of the most prevalent cancers that threaten people in many countries. It is a multi-factorial chronic disease caused by a combination of genetic and environmental factors, but it is mainly related to lifestyle factors, including diet. Plentiful plant foods and beverages are abundant in polyphenols with antioxidant, anti-atherosclerotic, anti-inflammatory, and anticancer properties. These compounds participate in host nutrition and disease pathology regulation in different ways. Polyphenolic compounds have been used to prevent and inhibit the development and prognosis of cancer, and examples include green tea polyphenol (-)epigallocatechin-3-O-gallate (EGCG), curcumin, and resveratrol. Of course, there are more known and unknown polyphenol compounds that need to be further explored for their anticancer properties. This article focuses on the fact that polyphenols affect the progression of CRC by controlling intestinal inflammation, epigenetics, and the intestinal microbe in the aspects of prevention, treatment, and prognosis.

引用

页数：9

共 108 条

[1] Prospective Association between Total and Specific Dietary Polyphenol Intakes and Cardiovascular Disease Risk in the Nutrinet-Sante French Cohort [J].