Prevention and Treatment of Venous Thromboembolism in Pregnancy

被引:22
作者
James, Andra H. [1 ]
机构
[1] Duke Univ, Med Ctr, Dept Obstet & Gynecol, Div Maternal Fetal Med, Durham, NC 27710 USA
关键词
thromboembolism; pregnancy; postpartum; anticoagulation; heparin; MOLECULAR-WEIGHT HEPARIN; DEEP-VEIN THROMBOSIS; PULMONARY-EMBOLISM; RISK-FACTORS; UNFRACTIONATED HEPARIN; ANTICOAGULANT-THERAPY; POSTPARTUM PERIOD; UNITED-STATES; HEART-VALVES; BED REST;
D O I
10.1097/GRF.0b013e31825cfe7b
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
During pregnancy, women have a 4- to 5-fold increased risk of thromboembolism. Candidates for anticoagulation in pregnancy include women with current thrombosis, a history of thrombosis, risk factors for postpartum thrombosis, and some women with thrombophilia and a history of poor pregnancy outcome. Although, there are no large trials of anticoagulants in pregnancy and recommendations for their use are based on case series and the opinion of experts, observational studies demonstrate the benefit of heparins in reducing the risk of recurrent thromboembolism in pregnancy. A practical approach to the prevention and treatment of thromboembolism in pregnancy is outlined.
引用
收藏
页码:774 / 787
页数:14
相关论文
共 92 条
  • [1] Efficacy and safety of once daily low molecular weight heparin (tinzaparin sodium) in high risk pregnancy
    Ainle, Fionnuala Ni
    Wong, Audris
    Appleby, Niamh
    Byrne, Brigitte
    Regan, Carmen
    Hassan, Tayyaba
    Milner, Marie
    Sullivan, Ann O.
    White, Barry
    O'Donnell, James
    [J]. BLOOD COAGULATION & FIBRINOLYSIS, 2008, 19 (07) : 689 - 692
  • [2] American Academy of Pediatrics Committee on Drugs, 2001, Pediatrics, V108, P776
  • [3] The cumulative Incidence of venous thromboembolism during pregnancy and puerperium - An 11 year Danish population-based study of 63,300 pregnancies
    Andersen, BS
    Steffensen, FH
    Sorensen, HT
    Nielsen, GL
    Olsen, J
    [J]. ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA, 1998, 77 (02) : 170 - 173
  • [4] A prospective triat that demonstrates that dalteparin requirements increase in pregnancy to maintain therapeutic levets of anticoagulation
    Barbour, LA
    Oja, JL
    Schultz, LK
    [J]. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2004, 191 (03) : 1024 - 1029
  • [5] Venous thromboembolism, thrombophilia, antithrombotic therapy, and pregnancy
    Bates, Shannon M.
    Greer, Ian A.
    Pabinger, Ingrid
    Sofaer, Shoshanna
    Hirsh, Jack
    [J]. CHEST, 2008, 133 (06) : 844S - 886S
  • [6] VTE, Thrombophilia, Antithrombotic Therapy, and Pregnancy Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines
    Bates, Shannon M.
    Greer, Ian A.
    Middeldorp, Saskia
    Veenstra, David L.
    Prabulos, Anne-Marie
    Vandvik, Per Olav
    [J]. CHEST, 2012, 141 (02) : E691S - E736S
  • [7] Pregnancy-Related Mortality in the United States, 1998 to 2005
    Berg, Cynthia J.
    Callaghan, William M.
    Syverson, Carla
    Henderson, Zsakeba
    [J]. OBSTETRICS AND GYNECOLOGY, 2010, 116 (06) : 1302 - 1309
  • [8] Venous thromboembolism during pregnancy, postpartum or during contraceptive use Findings from the RIETE Registry
    Blanco-Molina, Angeles
    Rota, Lidia
    Di Micco, Pierpaolo
    Brenner, Benjamin
    Trujillo-Santos, Javier
    Ruiz-Gamietea, Angeles
    Monreal, Manuel
    [J]. THROMBOSIS AND HAEMOSTASIS, 2010, 103 (02) : 306 - 311
  • [9] The risk of fetal loss associated with Warfarin anticoagulation
    Blickstein, D
    Blickstein, I
    [J]. INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS, 2002, 78 (03) : 221 - 225
  • [10] Outbreak of Adverse Reactions Associated with Contaminated Heparin
    Blossom, David B.
    Kallen, Alexander J.
    Patel, Priti R.
    Elward, Alexis
    Robinson, Luke
    Gao, Ganpan
    Langer, Robert
    Perkins, Kiran M.
    Jaeger, Jennifer L.
    Kurkjian, Katie M.
    Jones, Marilyn
    Schillie, Sarah F.
    Shehab, Nadine
    Ketterer, Daniel
    Venkataraman, Ganesh
    Kishimoto, Takashi Kei
    Shriver, Zachary
    McMahon, Ann W.
    Austen, K. Frank
    Kozlowski, Steven
    Srinivasan, Arjun
    Turabelidze, George
    Gould, Carolyn V.
    Arduino, Matthew J.
    Sasisekharan, Ram
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2008, 359 (25) : 2674 - 2684