Inhibitory effects of macelignan isolated from Myristica fragrans HOUTT. on melanin biosynthesis

被引：23
作者：
Cho, Yumi [1 ]
Kim, Kyu-Hoi [1 ]
Shim, Jae-Seok [1 ]
Hwang, Jae-Kwan [1 ]
机构：
[1] Yonsei Univ, Dept Biotechnol, Seoul 120749, South Korea
来源：
BIOLOGICAL & PHARMACEUTICAL BULLETIN | 2008年 / 31卷 / 05期
关键词：
tyrosinase; tyrosinase-related protein; melanin; skin-whitening; macelignan; Myristica fragrans;
D O I：
10.1248/bpb.31.986
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The aim of this study was to investigate the in vitro inhibitory effects of macelignan isolated from Myristica fragrans HOUTT. on melanogenesis and its related enzymes such as tyrosinase, tyrosinase-related protein-1 (TRP-1), and tyrosinase-related protein-2 (TRP-2) in melan-a murine melanocytes. The IC50 values of macelignan for melanogenesis and tyrosinase were 13 mu M and 30 mu M, respectively, while those of arbutin as a positive control were 990 mu M and 660 mu M, respectively. In Western blot analysis, macelignan also significantly decreased tyrosinase, TRP-1, and TRP-2 protein expression. These results indicate that macelignan effectively inhibits melanin biosynthesis and thus could be employed as a new skin-whitening agent.
引用
收藏
页码：986 / 989
页数：4
相关论文
共 44 条
[1]   Plants used in cosmetics [J].
Aburjai, T ;
Natsheh, FM .
PHYTOTHERAPY RESEARCH, 2003, 17 (09) :987-1000
[2]   Chemical and instrumental approaches to treat hyperpigmentation [J].
Briganti, S ;
Camera, E ;
Picardo, M .
PIGMENT CELL RESEARCH, 2003, 16 (02) :101-110
[3]   KOJIC ACID, A COSMETIC SKIN WHITENING AGENT, IS A SLOW-BINDING INHIBITOR OF CATECHOLASE ACTIVITY OF TYROSINASE [J].
CABANES, J ;
CHAZARRA, S ;
GARCIACARMONA, F .
JOURNAL OF PHARMACY AND PHARMACOLOGY, 1994, 46 (12) :982-985
[4]   Anticariogenic activity of macelignan isolated from Myristica fragrans (nutmeg) against Streptococcus mutans [J].
Chung, JY ;
Choo, JH ;
Lee, MH ;
Hwang, J .
PHYTOMEDICINE, 2006, 13 (04) :261-266
[5]   Inhibitors of mammalian melanocyte tyrosinase:: In vitro comparisons of alkyl esters of gentisic acid with other putative inhibitors [J].
Curto, EV ;
Kwong, C ;
Hermersdörfer, H ;
Glatt, H ;
Santis, C ;
Virador, V ;
Hearing, VJ ;
Dooley, TP .
BIOCHEMICAL PHARMACOLOGY, 1999, 57 (06) :663-672
[6]  
DOOLEY TP, 1994, SKIN PHARMACOL, V7, P188
[7]   The combination of glycolic acid and hydroquinone or kojic acid for the treatment of melasma and related conditions [J].
Garcia, A ;
Fulton, JE .
DERMATOLOGIC SURGERY, 1996, 22 (05) :443-447
[8]   TOPICAL TRETINOIN (RETINOIC ACID) IMPROVES MELASMA - A VEHICLE-CONTROLLED, CLINICAL-TRIAL [J].
GRIFFITHS, CEM ;
FINKEL, LJ ;
DITRE, CM ;
HAMILTON, TA ;
ELLIS, CN ;
VOORHEES, JJ .
BRITISH JOURNAL OF DERMATOLOGY, 1993, 129 (04) :415-421
[9]   The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer [J].
Hakozaki, T ;
Minwalla, L ;
Zhuang, J ;
Chhoa, M ;
Matsubara, A ;
Miyamoto, K ;
Greatens, A ;
Hillebrand, GG ;
Bissett, DL ;
Boissy, RE .
BRITISH JOURNAL OF DERMATOLOGY, 2002, 147 (01) :20-31
[10]  
HEARING VJ, 1987, METHOD ENZYMOL, V142, P154
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