Contamination control is of critical importance for the success of most aerospace programs. Thermal control surfaces, solar arrays, and optical devices may be adversely affected by even miniscule levels of molecular and/or particulate contamination. There is a wealth of data available on the subject of contamination and its effect on specific spacecraft systems. However, what is rarely discussed are how one: a) quantifies the level of contamination that must be maintained in order for the system to function properly, and b) enforces contamination control to ensure compliance with requirements. This paper summarizes recent efforts to addresses these specific issues which have culminated in the development of a handbook on contamination control that illustrates process and methodology while providing direction to more detailed references as needed.