Wide 3-Dimensional Macular Ganglion Cell Complex Imaging with Spectral-Domain Optical Coherence Tomography in Glaucoma

被引：31

作者：

Morooka, Satoshi ^{[1
]}

Hangai, Masanori ^{[1
]}

Nukada, Masayuki ^{[1
]}

Nakano, Noriko ^{[1
]}

Takayama, Kohei ^{[1
]}

Kimura, Yugo ^{[1
]}

Akagi, Tadamichi ^{[1
]}

Ikeda, Hanako Ohashi ^{[1
]}

Nonaka, Atsushi ^{[1
]}

Yoshimura, Nagahisa ^{[1
]}

机构：

[1] Kyoto Univ, Dept Ophthalmol & Visual Sci, Grad Sch Med, Sakyo Ku, Kyoto 6068507, Japan

来源：

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE | 2012年 / 53卷 / 08期

基金：

日本学术振兴会;

关键词：

NERVE-FIBER LAYER; HUMAN EYES; PREPERIMETRIC GLAUCOMA; THICKNESS; VOLUME; NEUROPATHY; DIAGNOSIS; RETINA; DAMAGE; OCT;

D O I：

10.1167/iovs.12-9870

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

PURPOSE. To determine whether measurement of ganglion cell complex (GCC) thickness over a wide area (8-mm diameter) can improve the glaucoma-discriminating ability of spectral-domain optical coherence tomography (SD-OCT) compared to that in the standard macular area (6-mm diameter). METHODS. Ninety-three subjects were enrolled, including 46 healthy eyes of 46 volunteers and 47 eyes of 47 glaucoma patients (23 eyes with preperimetric glaucoma [PPG] and 24 eyes with early glaucoma [EG]). All patients underwent SD-OCT raster scanning over a 9 mmx9 mm square area centered on the fovea. Areas under the receiver operating characteristic curves (AROCs) were compared between wide sector (1-8-mm ring) and standard-size sector (1-6-mm ring) charts. RESULTS. AROCs for average GCC thickness in the wide chart were significantly greater than those of the standard chart in eyes with PPG (0.928 vs. 0.891; P = 0.038), EG (0.912 vs. 0.861; P = 0.003), and both (0.920 vs. 0.876; P = 0.004). Overall, the AROCs of regional GCC thicknesses were nearly comparable between the middle ring (4-6 mm) and outer ring (6-8 mm). Coefficients of variation were 0.68% and 0.97% in the standard and wide sector charts, respectively, in eyes with PPG, and 0.45% and 0.72% in the standard and wide sector charts, respectively, in eyes with EG. CONCLUSIONS. Addition of the GCC thickness outside the macula to the standard macular GCC thickness significantly increased the glaucoma-discriminating ability of SD-OCT. (Invest Ophthalmol Vis Sci. 2012;53:4805-4812) DOI: 10.1167/iovs.12-9870

引用

页码：4805 / 4812

页数：8