Treatment of VGKC Complex Antibody-Associated Limbic Encephalitis: A Systematic Review

被引：21

作者：

Radja, Guirindhra Koumar ^{[1
]}

Cavanna, Andrea Eugenio ^{[2
,3
,4
,5
]}

机构：

[1] South Staffordshire & Shropshire NHS Fdn Trust UK, Birmingham, W Midlands, England

[2] Univ Birmingham, Michael Trimble Neuropsychiat Res Grp, Birmingham, W Midlands, England

[3] BSMHFT, Birmingham, W Midlands, England

[4] UCL, Sobell Dept Motor Neurosci & Movement Disorders, London, England

[5] Inst Neurol, London WC1N 3BG, England

来源：

JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES | 2013年 / 25卷 / 04期

关键词：

POTASSIUM-CHANNEL ANTIBODY; ENCEPHALOPATHY; DISORDER; AMNESIA; DISEASE; ONSET;

D O I：

10.1176/appi.neuropsych.13020022

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Limbic encephalitis is an autoimmune neuropsychiatric condition characterized by subacute cognitive symptoms, seizures, and affective changes. Although limbic encephalitis is usually caused by an immune reaction secondary to neoplasms, different types of potentially treatable non-paraneoplastic limbic encephalitis (nPLE) have recently been described. In particular, published studies have reported variable responses to immunosuppressive therapy in Voltage-Gated Potassium Channel (VGKC) complex antibody-associated nPLE. This systematic literature review found that the most significant improvements were reported by patients presenting with affective symptoms and consistent neuroradiological changes. In these patients, improved clinical outcomes correlated with the largest decreases in antibody titers.

引用

页码：264 / 271

页数：8

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