Yeast autophagosomes:: de novo formation of a membrane structure

被引：158

作者：

Noda, T ^{[1
]}

Suzuki, K ^{[1
]}

Ohsumi, Y ^{[1
]}

机构：

[1] Natl Inst Basic Biol, Dept Cell Biol, Okazaki, Aichi 4448585, Japan

来源：

TRENDS IN CELL BIOLOGY | 2002年 / 12卷 / 05期

关键词：

D O I：

10.1016/S0962-8924(02)02278-X

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Autophagy - the degradation of organelles and cytoplasmic material-occurs through dynamic rearrangements of cellular membrane structures. Following the induction of autophagy, newly formed autophagosomes transfer cytosolic materials to the lysosome or vacuole for degradation, The autophagosome is an organelle destined for degradation, suggesting that the membrane structure is formed de novo many times. The autophagosome is formed through the nucleation, assembly and elongation of membrane structures. The concerted action of several Apg/Aut/Cvt proteins around a characteristic subcellular structure (the preautophagosomal structure) is the key to understanding this novel type of membrane-formation process.

引用

页码：231 / 235

页数：5

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