Interest of the radiotherapy-hormonotherapy association in the treatment of the high-risk prostate cancer

被引：1
|
作者：
Bolla, M. [1 ]
Fourneret, P. [1 ]
Descotes, J. -L. [2 ]
机构：
[1] CHU, Clin Univ Cancerol Radiotherapie, F-63011 Grenoble, France
[2] CHU, Clin Univ Urol, F-63011 Grenoble, France
来源：
BULLETIN DU CANCER | 2008年 / 95卷 / 12期
关键词：
high-risk prostate cancer; combination of external irradiation and androgen suppression;
D O I：
10.1684/bdc.2008.0755
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Treatment of high-risk prostate cancer-localized or locally advanced-is based on the combination of external irradiation and hormonal treatment by LHRH analogue (aLHRH) according to the results of phases III randomized trials RTOG and/or EORTC trials. These trials show a significant improvement of overall or specific survival. Localized prostate cancer require 6-month complete androgen blockade, while locally advanced prostate cancer need a long-term hormonal treatment for a duration ranging from 2,5 to 3 years. Some trials, which have a long follow-up show that the risk of cardiovascular death is not significantly increased by hormonal treatment.
引用
收藏
页码：1213 / 1218
页数：6
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