Inhibition of herpesvirus and influenza virus replication by blocking polymerase subunit interactions

被引：15
作者：
Palu, Giorgio [1 ]
Loregian, Arianna [1 ]
机构：
[1] Univ Padua, Dept Mol Med, I-35121 Padua, Italy
来源：
ANTIVIRAL RESEARCH | 2013年 / 99卷 / 03期
关键词：
Protein-protein interaction; Herpesvirus; Influenza virus; Viral polymerase; Antiviral therapy; CYTOMEGALOVIRUS DNA-POLYMERASE; SARCOMA-ASSOCIATED HERPESVIRUS; PROTEIN-PROTEIN INTERACTIONS; PROCESSIVITY FACTOR PPUL44; KAPOSIS-SARCOMA; C-TERMINUS; ACCESSORY PROTEIN; RNA-POLYMERASE; CATALYTIC SUBUNIT; VIRAL REPLICATION;
D O I：
10.1016/j.antiviral.2013.05.014
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Protein-protein interactions (PPIs) play a key role in many biological processes, including virus replication in the host cell. Since most of the PPIs are functionally essential, a possible strategy to inhibit virus replication is based on the disruption of viral protein complexes by peptides or small molecules that interfere with subunit interactions. In particular, an attractive target for antiviral drugs is the binding between the subunits of essential viral enzymes. This review describes the development of new antiviral compounds that inhibit herpesvirus and influenza virus replication by blocking interactions between subunit proteins of their polymerase complexes. (C) 2013 Elsevier B.V. All rights reserved.
引用
收藏
页码：318 / 327
页数：10
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