A near-infrared fluorescent probe based on nucleophilic substitution-cyclization for selective detection of hydrogen sulfide and bioimaging

被引：52
作者：
Men, Jinxia [1 ]
Yang, Xiaojun [2 ,3 ]
Zhang, Huibin [2 ,3 ]
Zhou, Jinpei [1 ]
机构：
[1] China Pharmaceut Univ, Dept Med Chem, Nanjing 210009, Jiangsu, Peoples R China
[2] China Pharmaceut Univ, Ctr Drug Discovery, State Key Lab Nat Med, Nanjing 210009, Jiangsu, Peoples R China
[3] China Pharmaceut Univ, Jiangsu Key Lab Drug Discovery Metab Dis, Nanjing 210009, Jiangsu, Peoples R China
来源：
DYES AND PIGMENTS | 2018年 / 153卷
关键词：
Fluorescence probe; Near-infrared; H2S; Cell imaging; BIOLOGICAL-SYSTEMS; LIVING CELLS; H2S; GASOTRANSMITTER; VISUALIZATION; PLATFORMS; CYSTEINE; RELEASE; SENSOR; BRAIN;
D O I：
10.1016/j.dyepig.2017.12.036
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Endogenous hydrogen sulfide (H2S) has been acknowledged as the third important gasotransmitter and plays a vital role to human health and diseases. A "turn-on" near-infrared fluorescent probe DCM-PBA based on nucleophilic substitution-cyclization has been developed for the detection of hydrogen sulfide. The probe showed high selectivity and sensitivity toward H2S and was successfully applied to imaging H2S in Hela cells.
引用
收藏
页码：206 / 212
页数：7
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