Water soluble sulconazole-β-cyclodextrin complex: physico-chemical characterization and preliminary pharmacological studies

被引：7

作者：

Miron, Liviu ^{[1
,2
]}

Mares, Mihai ^{[1
,3
]}

Nastasa, Valentin ^{[1
,4
]}

Spulber, Mariana ^{[1
]}

Fifere, Adrian ^{[1
]}

Pinteala, Mariana ^{[1
]}

Harabagiu, Valeria ^{[1
]}

Simionescu, Bogdan C. ^{[1
]}

机构：

[1] Petru Poni Inst Macromol Chem, R-6600 Iasi, Romania

[2] Univ Agr Sci & Vet Med Ion Ionescu Brad, Dept Parasitol, Iasi, Romania

[3] Univ Agr Sci & Vet Med, Dept Mycol Mycotoxicol, Iasi, Romania

[4] Univ Agr Sci & Vet Med, Dept Pharmacol, Iasi, Romania

来源：

JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY | 2009年 / 63卷 / 1-2期

关键词：

Sulconazole nitrate; Cyclodextrin; Antifungal activity; Acute toxicity;

D O I：

10.1007/s10847-008-9501-x

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Sulconazole-beta-cyclodextrin water soluble inclusion complex was prepared by freeze drying method in distilled water. The formation of inclusion complex between beta-cyclodextrin and sulconazole has been studied in a previous work. Preliminary pharmacological studies concerning the antifungal activity showed that the minimal inhibitory concentrations for 90% of the tested strains decreased. Also, the acute toxicity of the sulconazole-beta-cyclodextrin complex is smaller comparing with the pure drug, analyzed alone. These results recommend the described conjugates as future promising therapeutic agents.

引用

页码：159 / 162

页数：4

共 10 条

[1]

COMO JA, 1994, NEW ENGL J MED, V330, P263, DOI 10.1056/NEJM199401273300407

[2]

DIXON VJ, 1948, J AM STAT ASSOC, V43, P109

[3]

HETHERINGTON SV, 1997, PRIN PRACT PEDIAT IN, P1663

[4]

NOSANCHUK DJ, 2006, RECENT PATENTS ANTII, V1, P36

[5]

OECD, 2000, ENV HLTH SAF MON SER, V19

[6]

OECD, 2000, Guidance Document on the Recognition

[7] Inclusion complexes of Sulconazole with β-cyclodextrin and hydroxypropyl β-cyclodextrin:: characterization in aqueous solution and in solid state [J].

Spulber, Mariana ;

Pinteala, Mariana ;

Harbagiu, Valeria ;

Simionescu, Bogdan C. .

JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY, 2008, 61 (1-2) :41-51

[8]

STOESCU V, 2001, BAZELE FARMACOLOGICE

[9] Past, present, and future of cyclodextrin research [J].

Szejtli, J .

PURE AND APPLIED CHEMISTRY, 2004, 76 (10) :1825-1845

[10]

VANDENBOSSCHE H, 1990, BIOCHEM SOC T, V18, P56

← 1 →