Effect of Protein Kinase Cβ Inhibition on Renal Hemodynamic Function and Urinary Biomarkers in Humans With Type 1 Diabetes: A Pilot Study

被引：35

作者：

Cherney, David Z. I. ^{[1
]}

Konvalinka, Ana ^{[2
]}

Zinman, Bernard ^{[3
]}

Diamandis, Eleftherios P.

Soosaipillai, Anton ^{[4
]}

Reich, Heather ^{[1
]}

Lorraine, Joanne ^{[5
]}

Lai, Vesta ^{[1
]}

Scholey, James W. ^{[1
]}

Miller, Judith A. ^{[1
]}

机构：

[1] Univ Hlth Network, Div Med, Toronto, ON, Canada

[2] Univ Hlth Network, Div Nephrol, Toronto, ON, Canada

[3] Mt Sinai Hosp, Div Med, Samuel Lunenfeld Res Inst, Leadership Sinai Ctr Diabet, Toronto, ON M5G 1X5, Canada

[4] Mt Sinai Hosp, Div Lab Med & Pathol, Toronto, ON M5G 1X5, Canada

[5] Eli Lilly & Co, Toronto, ON, Canada

来源：

DIABETES CARE | 2009年 / 32卷 / 01期

关键词：

EPIDERMAL-GROWTH-FACTOR; NEPHROPATHY; DISEASE; RATS;

D O I：

10.2337/dc08-1609

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

OBJECTIVE - The aim of this study was to examine the effect of protein kinase C beta inhibition with ruboxistaurin on renal hemodynamic function and urinary biomarkers (monocyte chemoattractant protem-1 [MCP-1] and epidermal growth factor) in renin angiotensin system blockade-treated type I diabetic subjects. RESEARCH DESIGN AND METHODS - Albuminuric subjects were randomized (2: 1) to ruboxistaurin (32 mg daily; it = 13) or placebo (n = 7) for 8 weeks. Renal hemodynainic function was measured during clamped euglycemia or hyperglycemia and before and after ruboxistaurin or placebo. RESULTS - Ruboxistaurin was not associated with between-group differences during clamped euglycemia or hyperglycemia. In a post hoc analysis comparing hyperfilterers with normofilterers during euglycemia, glomerular filtration rate and MCP-1 decreased, whereas the epidermal growth factor-to-MCP-1 ratio increased in hyperfilterers versus normofilterers (all P < 0.05). CONCLUSIONS - The effect of ruboxistaurin is modest and dependent, at least in part, on the level of ambient glycemia and baseline glomerular filtration rate.

引用

页码：91 / 93

页数：3

共 12 条

[1] The effect of cyclooxygenase-2 inhibition on renal. Hemodynamic function in humans with type 1 diabetes [J].