Pitfalls in Diagnosis of Pediatric Clostridium difficile Infection

被引：17
作者：
Sammons, Julia S. [1 ]
Toltzis, Philip [2 ]
机构：
[1] Univ Penn, Childrens Hosp Philadelphia, Perelman Sch Med, Div Infect Dis,Dept Infect Prevent & Control, Philadelphia, PA 19104 USA
[2] Case Western Reserve Univ, Sch Med, Rainbow Babies & Childrens Hosp, Div Pediat Crit Care, Cleveland, OH 44106 USA
来源：
INFECTIOUS DISEASE CLINICS OF NORTH AMERICA | 2015年 / 29卷 / 03期
关键词：
Clostridium difficile; Diagnosis; Diarrhea; Pediatrics; POLYMERASE-CHAIN-REACTION; POINT-PREVALENCE SURVEY; ENZYME-IMMUNOASSAY; STOOL SAMPLES; RISK-FACTORS; GLUTAMATE-DEHYDROGENASE; YOUNG-CHILDREN; UNITED-STATES; TOXIN; INFANTS;
D O I：
10.1016/j.idc.2015.05.010
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The incidence of Clostridium difficile infection (CDI) has risen among children and C difficile is increasingly recognized as an important cause of healthcare-associated diarrhea among pediatric patients. Still, increased identification of CDI in healthy children in the community and increased testing among infants requires cautious interpretation, given the high prevalence of asymptomatic colonization in young infants and frequent detection of viruses and other co-pathogens in stool specimens in these age groups. The significance of CDI among infants and the implications of positive C difficile testing among healthy children in the community are areas in need of further study.
引用
收藏
页码：465 / +
页数：13
相关论文
共 79 条
[1]   CLOSTRIDIUM-DIFFICILE ASSOCIATED WITH PSEUDO-MEMBRANOUS COLITIS - OCCURRENCE IN A 12-WEEK-OLD INFANT WITHOUT PRIOR ANTIBIOTIC-THERAPY [J].
ADLER, SP ;
CHANDRIKA, T ;
BERMAN, WF .
AMERICAN JOURNAL OF DISEASES OF CHILDREN, 1981, 135 (09) :820-822
[2]   Clinical relevance of a positive molecular test in the diagnosis of Clostridium difficile infection [J].
Baker, I. ;
Leeming, J. P. ;
Reynolds, R. ;
Ibrahim, I. ;
Darley, E. .
JOURNAL OF HOSPITAL INFECTION, 2013, 84 (04) :311-315
[3]   Changing epidemiology of Clostridium difficile-associated disease in children [J].
Benson, Lacey ;
Song, Xiaoyan ;
Campos, Joseph ;
Singh, Nalini .
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY, 2007, 28 (11) :1233-1235
[4]   CLOSTRIDIUM-DIFFICILE IN A PEDIATRIC OUTPATIENT POPULATION [J].
BOENNING, DA ;
FLEISHER, GR ;
CAMPOS, JM ;
HULKOWER, CW ;
QUINLAN, RW .
PEDIATRIC INFECTIOUS DISEASE JOURNAL, 1982, 1 (05) :336-338
[5]   Clostridium difficile Infection in Ohio Hospitals and Nursing Homes During 2006 [J].
Campbell, Robert J. ;
Giljahn, Lynn ;
Machesky, Kim ;
Cibulskas-White, Katie ;
Lane, Lisa M. ;
Porter, Kyle ;
Paulson, John O. ;
Smith, Forrest W. ;
McDonald, L. Clifford .
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY, 2009, 30 (06) :526-533
[6]  
Centers for Disease Control and Prevention (CDC), 2005, MMWR Morb Mortal Wkly Rep, V54, P1201
[7]   Epidemiology of Community-Associated Clostridium difficile Infection, 2009 Through 2011 [J].
Chitnis, Amit S. ;
Holzbauer, Stacy M. ;
Belflower, Ruth M. ;
Winston, Lisa G. ;
Bamberg, Wendy M. ;
Lyons, Carol ;
Farley, Monica M. ;
Dumyati, Ghinwa K. ;
Wilson, Lucy E. ;
Beldavs, Zintars G. ;
Dunn, John R. ;
Gould, L. Hannah ;
MacCannell, Duncan R. ;
Gerding, Dale N. ;
McDonald, L. Clifford ;
Lessa, Fernanda C. .
JAMA INTERNAL MEDICINE, 2013, 173 (14) :1359-1367
[8]   Clinical Practice Guidelines for Clostridium difficile Infection in Adults: 2010 Update by the Society for Healthcare Epidemiology of America (SHEA) and the Infectious Diseases Society of America (IDSA) [J].
Cohen, Stuart H. ;
Gerding, Dale N. ;
Johnson, Stuart ;
Kelly, Ciaran P. ;
Loo, Vivian G. ;
McDonald, L. Clifford ;
Pepin, Jacques ;
Wilcox, Mark H. .
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY, 2010, 31 (05) :431-455
[9]   European Society of Clinical Microbiology and Infectious Diseases (ESCMID): Data review and recommendations for diagnosing Clostridium difficile-infection (CDI) [J].
Crobach, M. J. T. ;
Dekkers, O. M. ;
Wilcox, M. H. ;
Kuijper, E. J. .
CLINICAL MICROBIOLOGY AND INFECTION, 2009, 15 (12) :1053-1066
[10]   Trends in Clostridium difficile Infection and Risk Factors for Hospital Acquisition of Clostridium difficile among Children with Cancer [J].
de Blank, Peter ;
Zaoutis, Theoklis ;
Fisher, Brian ;
Troxel, Andrea ;
Kim, Jason ;
Aplenc, Richard .
JOURNAL OF PEDIATRICS, 2013, 163 (03) :699-+
12345678