Zinc and myocardial ischemia/reperfusion injury

被引：55
|
作者：
Xu, Zhelong [1 ]
Zhou, Juan [2 ]
机构：
[1] Tianjin Med Univ, Dept Physiol & Pathophysiol, Tianjin 300070, Peoples R China
[2] Xi An Jiao Tong Univ, Dept Physiol & Pathophysiol, Xian 710061, Shanxi, Peoples R China
来源：
BIOMETALS | 2013年 / 26卷 / 06期
关键词：
Zinc; Zinc homeostasis; Zinc transporters; Zinc signaling; Myocardial ischemia/reperfusion injury; PROTEIN-KINASE-C; GLYCOGEN-SYNTHASE KINASE-3-BETA; TRANSCRIPTION FACTOR MTF-1; CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE; TYROSINE-PHOSPHATASE ACTIVITY; PERMEABILITY TRANSITION PORE; ISCHEMIA-REPERFUSION INJURY; P70; S6; KINASE; MAMMALIAN ZINC; INTRACELLULAR ZINC;
D O I：
10.1007/s10534-013-9671-x
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
As an important trace element, zinc is required for the normal cellular structure and function, and impairment of zinc homeostasis is associated with a variety of health problems including cardiovascular disease. Zinc homeostasis is regulated through zinc transporters, zinc binding molecules, and zinc sensors. Zinc also plays a critical role in cellular signaling. Studies have documented that zinc homeostasis is impaired by ischemia/reperfusion in the heart and zinc dyshomeostasis may play a role in the pathogenesis of myocardial ischemia/reperfusion injury. Both exogenous and endogenously released zinc may play an important role in cardioprotection against ischemia/reperfusion injury. The goal of this review is to summarize the current understanding of the roles of zinc homeostasis and zinc signaling in myocardial ischemia/reperfusion injury.
引用
收藏
页码：863 / 878
页数：16
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