Zinc and myocardial ischemia/reperfusion injury

被引：56

作者：

Xu, Zhelong ^{[1
]}

Zhou, Juan ^{[2
]}

机构：

[1] Tianjin Med Univ, Dept Physiol & Pathophysiol, Tianjin 300070, Peoples R China

[2] Xi An Jiao Tong Univ, Dept Physiol & Pathophysiol, Xian 710061, Shanxi, Peoples R China

来源：

BIOMETALS | 2013年 / 26卷 / 06期

关键词：

Zinc; Zinc homeostasis; Zinc transporters; Zinc signaling; Myocardial ischemia/reperfusion injury; PROTEIN-KINASE-C; GLYCOGEN-SYNTHASE KINASE-3-BETA; TRANSCRIPTION FACTOR MTF-1; CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE; TYROSINE-PHOSPHATASE ACTIVITY; PERMEABILITY TRANSITION PORE; ISCHEMIA-REPERFUSION INJURY; P70; S6; KINASE; MAMMALIAN ZINC; INTRACELLULAR ZINC;

D O I：

10.1007/s10534-013-9671-x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

As an important trace element, zinc is required for the normal cellular structure and function, and impairment of zinc homeostasis is associated with a variety of health problems including cardiovascular disease. Zinc homeostasis is regulated through zinc transporters, zinc binding molecules, and zinc sensors. Zinc also plays a critical role in cellular signaling. Studies have documented that zinc homeostasis is impaired by ischemia/reperfusion in the heart and zinc dyshomeostasis may play a role in the pathogenesis of myocardial ischemia/reperfusion injury. Both exogenous and endogenously released zinc may play an important role in cardioprotection against ischemia/reperfusion injury. The goal of this review is to summarize the current understanding of the roles of zinc homeostasis and zinc signaling in myocardial ischemia/reperfusion injury.

引用

页码：863 / 878

页数：16

共 144 条

[1] Mechanism of zinc-induced phosphorylation of p70 S6 kinase and glycogen synthase kinase 3β in SH-SY5Y neuroblastoma cells [J].

An, WL ;

Bjorkdahl, C ;

Liu, R ;

Cowburn, RF ;

Winblad, B ;

Pei, JJ .

JOURNAL OF NEUROCHEMISTRY, 2005, 92 (05) :1104-1115

[2] Cellular zinc sensors: MTF-1 regulation of gene expression [J].

Andrews, GK .

BIOMETALS, 2001, 14 (3-4) :223-237

[3] Redox Regulation of Intracellular Zinc: Molecular Signaling in the Life and Death of Neurons [J].

Aras, Mandar A. ;

Aizenman, Elias .

ANTIOXIDANTS & REDOX SIGNALING, 2011, 15 (08) :2249-2263

[4] The functional significance of brain metallothioneins [J].

Aschner, M .

FASEB JOURNAL, 1996, 10 (10) :1129-1136

[5] The Zinc Transporter Zip14 Influences c-Met Phosphorylation and Hepatocyte Proliferation During Liver Regeneration in Mice [J].

Aydemir, Tolunay Beker ;

Sitren, Harry S. ;

Cousins, Robert J. .

GASTROENTEROLOGY, 2012, 142 (07) :1536-+

[6] Zinc modulates airway epithelium susceptibility to death receptor-mediated apoptosis [J].

Bao, SY ;

Knoell, DL .

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2006, 290 (03) :L433-L441

[7] Phosphoinositide 3-kinase signaling in the cellular response to oxidative stress [J].

Barthel, A ;

Klotz, LO .

BIOLOGICAL CHEMISTRY, 2005, 386 (03) :207-216

[8] Stimulation of phosphoinositide 3-kinase/Akt signaling by copper and zinc ions:: Mechanisms and consequences [J].

Barthel, Andreas ;

Ostrakhovitch, Elena A. ;

Walter, Philippe L. ;

Kampkoetter, Andreas ;

Klotz, Lars-Oliver .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2007, 463 (02) :175-182

[9] Is zinc deficiency a risk factor for atherosclerosis? [J].

Beattie, JH ;

Kwun, IS .

BRITISH JOURNAL OF NUTRITION, 2004, 91 (02) :177-181

[10] Mycobacterium bovis BCG cell wall and lipopolysaccharide induce a novel gene, BIGM103, encoding a 7-TM protein:: Identification of a new protein family having Zn-transporter and Zn-metalloprotease signatures [J].

Begum, NA ;

Kobayashi, M ;

Moriwaki, Y ;

Matsumoto, M ;

Toyoshima, K ;

Seya, T .

GENOMICS, 2002, 80 (06) :630-645

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