EARLY CHANGES OF MUSCLE INSULIN-LIKE GROWTH FACTOR-1 AND MYOSTATIN GENE EXPRESSION IN GASTRIC CANCER PATIENTS

被引：26

作者：

Bonetto, Andrea ^{[1
]}

Penna, Fabio ^{[1
]}

Aversa, Zaira ^{[2
]}

Mercantini, Paolo ^{[3
]}

Baccino, Francesco M. ^{[1
]}

Costelli, Paola ^{[1
]}

Ziparo, Vincenzo ^{[3
]}

Lucia, Simone ^{[2
]}

Rossi Fanelli, Filippo ^{[2
]}

Muscaritoli, Maurizio ^{[2
]}

机构：

[1] Univ Turin, Dept Expt Med & Oncol, Turin, Italy

[2] Univ Rome, Dept Clin Med, Rome, Italy

[3] Univ Rome, S Andrea Hosp, Dept Surg, Rome, Italy

来源：

MUSCLE & NERVE | 2013年 / 48卷 / 03期

关键词：

cachexia; human cancer; IGF-1; myostatin; ubiquitin ligases; SKELETAL-MUSCLE; THERAPEUTIC TARGET; BINDING-PROTEINS; CACHEXIA; MICE; INHIBITORS; DISEASE; WEIGHT; RATS;

D O I：

10.1002/mus.23798

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

IntroductionCachexia increases morbidity and mortality of cancer patients. The progressive loss of muscle mass negatively affects physical function and quality of life. We previously showed reduced muscle insulin-like growth factor-1 (IGF-1) expression and enhanced myostatin signaling in tumor-bearing animals. This study was aimed at investigating whether similar perturbations occur in gastric cancer patients. MethodsEarly perturbations of myostatin and IGF-1 signaling (including the expression of muscle-specific ubiquitin ligases) were investigated in 16 gastric cancer patients and in 6 controls by analyzing muscle mRNA expression with semiquantitative reverse transcriptase polymerase chain reaction (PCR) and real-time PCR. ResultsIn gastric cancer patients, muscle mRNA levels for IGF-1, myostatin, and atrogin-1 were reduced irrespective of weight loss (5% or >5%), whereas MuRF1 expression was unchanged. ConclusionsIGF-1 and myostatin mRNA levels are downregulated in gastric cancer patients who have minimal or no weight loss. These early alterations are particularly relevant in order to devise preventive and therapeutic strategies for cancer cachexia. Muscle Nerve48: 387-392, 2013

引用

页码：387 / 392

页数：6

共 34 条

[1] Consensus on Cachexia Definitions [J].