Established methodological issues in electronic nose research: how far are we from using these instruments in clinical settings of breath analysis?

被引:65
作者
Bikov, Andras [1 ]
Lazar, Zsofia [1 ]
Horvath, Ildiko [1 ,2 ]
机构
[1] Semmelweis Univ, Dept Pulmonol, Budapest, Hungary
[2] Natl Koranyi Inst Pulmonol, Budapest, Hungary
关键词
electronic nose; Cyranose; 320; breath test;
D O I
10.1088/1752-7155/9/3/034001
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Electronic noses (e-noses) represent an easy and cheap method for exhaled volatile compound analysis. Various electronic noses are available which differ in material and thus analytical performance. In this review, we describe a wide range of electronic noses and summarize data on the methodological issues in electronic nose research. We also review studies which show the ability of electronic noses to distinguish pulmonary and extrapulmonary disorders from health.
引用
收藏
页数:18
相关论文
共 123 条
  • [1] Haick H., Broza Y.Y., Mochalski P., Ruzsanyi V., Amann A., Assessment, origin, and implementation of breath volatile cancer markers, Chem. Soc. Rev., 43, pp. 1423-1449, (2014)
  • [2] Wheelock C.E., Et al., Application of 'omics technologies to biomarker discovery in inflammatory lung diseases, Eur. Respir. J., 42, pp. 802-825, (2013)
  • [3] Montuschi P., Mores N., Trove A., Mondino C., Barnes P.J., The electronic nose in respiratory medicine, Respiration, 85, pp. 72-84, (2013)
  • [4] Rock F., Barsan N., Weimar U., Electronic nose: Current status and future trends, Chem. Rev., 108, pp. 705-725, (2008)
  • [5] Di Natale C., Paolesse R., D'Amico A., Metalloporphyrins based artificial olfactory receptors, Sensors Actuators, 121, pp. 238-246, (2007)
  • [6] Broza Y.Y., Haick H., Nanomaterial-based sensors for detection of disease by volatile organic compounds, Nanomedicine, 8, pp. 785-806, (2013)
  • [7] James D., Scott S.M., Ali Z., O'Hare W.T., Chemical sensors for electronic nose systems, Microchim. Acta, 149, pp. 1-17, (2005)
  • [8] Lewis N.S., Comparisons between mammalian and artificial olfaction based on arrays of carbon black-polymer composite vapor detectors, Acc. Chem. Res., 37, pp. 663-672, (2004)
  • [9] Van Der Schee M.P., Paff T., Brinkman P., Van Aalderen W.M.C., Haarman E.G., Sterk P.J., Breathomics in lung disease, Chest J., 147, pp. 224-231, (2015)
  • [10] Fens N., Schee M., Brinkman P., Sterk P., Exhaled breath analysis by electronic nose in airways disease. Established issues and key questions, Clin. Exp. Allergy, 43, pp. 705-715, (2013)