Multifunctionalized Sequence-Defined Oligomers from a Single Building Block

被引：186

作者：

Espeel, Pieter ^{[1
]}

Carrette, Lieselot L. G. ^{[2
]}

Bury, Katarzyna ^{[1
]}

Capenberghs, Sven ^{[1
]}

Martins, Jose C. ^{[3
]}

Du Prez, Filip E. ^{[1
]}

Madder, Annemieke ^{[2
]}

机构：

[1] Univ Ghent, Dept Organ Chem, Polymer Chem Res Grp, B-9000 Ghent, Belgium

[2] Univ Ghent, Dept Organ Chem, Organ & Biomimet Chem Res Grp, B-9000 Ghent, Belgium

[3] Univ Ghent, Dept Organ Chem, NMR & Struct Anal Res Grp, B-9000 Ghent, Belgium

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 50期

关键词：

chemoselectivity; sequence-defined oligomers; solid-phase synthesis; synthetic methods; thiolactone; PHASE PEPTIDE-SYNTHESIS; PRECISION POLYMERS; SYNTHETIC-POLYMERS; ONE-POT; POLYMERIZATION; MONOMER; COVALENT; AMINE; CLICK; THIOL;

D O I：

10.1002/anie.201307439

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Another link in the chain: A thiolactone-based approach for the preparation of multifunctionalized sequence-defined oligomeric structures on solid support was established. The iterative aminolysis/chain extension method with a single building block and a variety of commercial amines allowed for the protecting group free synthesis of various oligomeric motifs with a unique backbone and a preprogrammed organization of side chain functionalities. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：13261 / 13264

页数：4