Recent expansions in an emergent novel drug delivery technology: Emulgel

被引:135
作者
Ajazuddin [1 ]
Alexander, Amit [1 ]
Khichariya, Ajita [1 ]
Gupta, Saurabh [1 ,2 ]
Patel, Ravish J. [1 ,3 ]
Giri, Tapan Kumar [1 ]
Tripathi, Dulal Krishna [1 ]
机构
[1] Rungta Coll Pharmaceut Sci & Res, Bhilai, Chhattisgarh, India
[2] Wockhardt Res Ctr, Aurangabad, Maharashtra, India
[3] Charotar Univ Sci & Technol, Ramanbhai Patel Coll Pharm, Anand, Gujarat, India
关键词
Topical; Emulgel; Emulsion; Gelling agent; Thixotropic; Cosmetic; PE-BASED MICELLES; IN-VITRO; MYRISTATE MICROEMULSIONS; RHEOLOGICAL PROPERTIES; SOLUBLE DRUG; OIL; RELEASE; ANTIOXIDANT; EMULSION; FORMULATION;
D O I
10.1016/j.jconrel.2013.06.030
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Emulgel is an emerging topical drug delivery system to which if more effort is paid towards its formulation & development with more number of topically effective drugs it will prove a boon for derma care & cosmetology. Emulgels are either emulsion of oil in water or water in oil type, which is gelled by mixing it with gelling agent. Incorporation of emulsion into gel increases its stability & makes it a dual control release system. Due to lack of excess oily bases & insoluble excipients, it shows better drug release as compared to other topical drug delivery system. Presence of gel phase makes it a non greasy & favors good patient compliance. These reviews give knowledge about Emulgel including its properties, advantages, formulation considerations, and its recent advances in research field. All factors such as selection of gelling agent, oil agent, emulsifiers influencing the stability and efficacy of Emulgel are discussed. All justifications are described in accordance with the research work carried out by various scientists. These brief reviews on formulation method have been included. Current research works that carried out on Emulgel are also discussed and highlighted the wide utility of Emulgel in topical drug delivery system. After the vast study, it can be concluded that the Emulgels appear better & effective drug delivery system as compared to other topical drug delivery system. The comprehensive analysis of rheological and release properties will provide an insight into the potential usage of Emulgel formulation as drug delivery system. (C) 2013 Elsevier B. V. All rights reserved.
引用
收藏
页码:122 / 132
页数:11
相关论文
共 99 条
[1]   Synthesis, characterization and in vitro studies of pegylated melphalan conjugates [J].
Ajazuddin ;
Alexander, Amit ;
Amarji, Basant ;
Kanaujia, Parijat .
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 2013, 39 (07) :1053-1062
[2]   Advancement in stimuli triggered in situ gelling delivery for local and systemic route [J].
Ajazuddin ;
Alexander, Amit ;
Khan, Junaid ;
Giri, Tapan Kumar ;
Tripathi, Dulal Krishna ;
Saraf, Swarnlata ;
Saraf, Shailendra .
EXPERT OPINION ON DRUG DELIVERY, 2012, 9 (12) :1573-1592
[3]   Applications of novel drug delivery system for herbal formulations [J].
Ajazuddin ;
Saraf, S. .
FITOTERAPIA, 2010, 81 (07) :680-689
[4]  
Alexander A., 2011, INT J APPL BIOL PHAR, V2, P434
[5]   Approaches for breaking the barriers of drug permeation through transdermal drug delivery [J].
Alexander, Amit ;
Dwivedi, Shubhangi ;
Ajazuddin ;
Giri, Tapan K. ;
Saraf, Swarnlata ;
Saraf, Shailendra ;
Tripathi, Dulal Krishna .
JOURNAL OF CONTROLLED RELEASE, 2012, 164 (01) :26-40
[6]  
[Anonymous], 2010, INT J PHARM PHARM SC
[7]   Evolution of Topical NSAIDs in the Guidelines for Treatment of Osteoarthritis in Elderly Patients [J].
Arnstein, Paul M. .
DRUGS & AGING, 2012, 29 (07) :523-531
[8]  
Baboota S, 2007, PDA J Pharm Sci Technol, V61, P276
[9]  
Badilli U., 2012, CHROMATOGRAPHIA, P1
[10]  
Badilli U., 2013, J INCL PHENOM MACRO, P1